亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Treatment Modalities to Manage Hepatocellular Carcinoma Patients with Portal Vein Thrombus: A Systematic Review and Meta-Analysis

医学 索拉非尼 肝细胞癌 荟萃分析 门静脉血栓形成 内科学 随机对照试验 外科 肿瘤科 血栓形成
作者
B.L. Liu,Ronald Chow,Brandon M. Meyers,Natalie Grindrod,Gabriel Boldt,Aastha Malik,Meghan P. Jairam,Mayur Brahmania,Luciana C. C. Leite,S. Freiburger,Michael Lock
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier]
卷期号:117 (2): e319-e319
标识
DOI:10.1016/j.ijrobp.2023.06.2357
摘要

Purpose/Objective(s)Patients with hepatocellular carcinoma (HCC) and portal vein thrombosis (PVT) have poor outcomes and an effective treatment strategy has not been established. The aim of this review is to compare the effectiveness of available treatment options in preventing mortality.Materials/MethodsA search was conducted in PubMed, EMBASE and Cochrane CENTRAL from 2007 to 2022. Articles were screened to identify studies of HCC patients with PVT that reported on all-cause mortality using radical intent treatments. Study quality was assessed using the Cochrane Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-1). Mortality rates at prespecified timepoints between 6 and 24 months were extracted and summarized using a random-effects DerSimonian-Laird model. This review was registered a priori on PROSPERO (CRD42022290708).ResultsThe impact of radiotherapy (RT) on overall survival (OS) is similar to all other treatments including sorafenib. When comparing sorafenib to local modalities (Y90 and RT), the local treatments had a better OS (OR 2.20, 95% CI: 1.11 – 4.39), but this difference disappeared after 6-months. Indeed, within 6 months, Y90 provided the best OS. No significant differences were noticed from 12 to 24 months. Combination treatments appeared to provide a significant additional OS benefit with TACE+RT having an improved OS over TACE alone and RT alone, with the benefit extending to 24 months.Conclusionthis analysis of HCC patients with PVT reports on six cohorts, with a total sample size of 2,356 patients. The addition of localized treatment to systemic treatment appears to improve survival. Combining TACE and RT was also better than either modality alone. Further investigations should be conducted, to further understand the role of localized treatments. Patients with hepatocellular carcinoma (HCC) and portal vein thrombosis (PVT) have poor outcomes and an effective treatment strategy has not been established. The aim of this review is to compare the effectiveness of available treatment options in preventing mortality. A search was conducted in PubMed, EMBASE and Cochrane CENTRAL from 2007 to 2022. Articles were screened to identify studies of HCC patients with PVT that reported on all-cause mortality using radical intent treatments. Study quality was assessed using the Cochrane Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-1). Mortality rates at prespecified timepoints between 6 and 24 months were extracted and summarized using a random-effects DerSimonian-Laird model. This review was registered a priori on PROSPERO (CRD42022290708). The impact of radiotherapy (RT) on overall survival (OS) is similar to all other treatments including sorafenib. When comparing sorafenib to local modalities (Y90 and RT), the local treatments had a better OS (OR 2.20, 95% CI: 1.11 – 4.39), but this difference disappeared after 6-months. Indeed, within 6 months, Y90 provided the best OS. No significant differences were noticed from 12 to 24 months. Combination treatments appeared to provide a significant additional OS benefit with TACE+RT having an improved OS over TACE alone and RT alone, with the benefit extending to 24 months. this analysis of HCC patients with PVT reports on six cohorts, with a total sample size of 2,356 patients. The addition of localized treatment to systemic treatment appears to improve survival. Combining TACE and RT was also better than either modality alone. Further investigations should be conducted, to further understand the role of localized treatments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
13秒前
26秒前
jyy发布了新的文献求助10
30秒前
大个应助科研通管家采纳,获得10
35秒前
桑吉卓玛关注了科研通微信公众号
1分钟前
佟天问完成签到 ,获得积分10
1分钟前
迷茫的一代完成签到,获得积分10
1分钟前
爆米花应助wen采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
上官万仇发布了新的文献求助10
1分钟前
1分钟前
谷子完成签到 ,获得积分10
1分钟前
wen发布了新的文献求助10
1分钟前
jyy发布了新的文献求助10
1分钟前
1分钟前
领导范儿应助司徒灵松采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
3分钟前
小蘑菇应助满锅采纳,获得10
3分钟前
江潇发布了新的文献求助10
3分钟前
3分钟前
满锅发布了新的文献求助10
3分钟前
3分钟前
Swear完成签到 ,获得积分10
3分钟前
满锅完成签到,获得积分10
3分钟前
江潇完成签到,获得积分10
3分钟前
内向宛凝发布了新的文献求助10
3分钟前
jyy发布了新的文献求助10
3分钟前
3分钟前
3分钟前
敏1997发布了新的文献求助10
3分钟前
yhy发布了新的文献求助10
3分钟前
汉堡包应助敏1997采纳,获得30
3分钟前
思源应助yhy采纳,获得10
4分钟前
4分钟前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3244700
求助须知:如何正确求助?哪些是违规求助? 2888396
关于积分的说明 8252771
捐赠科研通 2556854
什么是DOI,文献DOI怎么找? 1385415
科研通“疑难数据库(出版商)”最低求助积分说明 650157
邀请新用户注册赠送积分活动 626265