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Individual and joint association of phenols, parabens, and phthalates with childhood lung function: Exploring the mediating role of peripheral immune responses

免疫系统 调解 分位数回归 全国健康与营养检查调查 环境卫生 联想(心理学) 心理学 临床心理学 免疫学 医学 统计 数学 人口 政治学 法学 心理治疗师
作者
Yiting Chen,Jinhong Wu,Rong Li,Wenhui Kang,Anda Zhao,Yong Yin,Shilu Tong,Jiajun Yuan,Shenghui Li
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:454: 131457-131457 被引量:18
标识
DOI:10.1016/j.jhazmat.2023.131457
摘要

The functioning of the respiratory system can be interfered with by exposure to mixtures of environmental chemicals, however, the evidence is still ambiguous. We evaluated the association of exposure to mixtures of 14 chemicals, including 2 phenols, 2 parabens, and 10 phthalates, with four major lung function metrics. Based on data from the National Health and Nutrition Examination Survey 2007–2012, this analysis was conducted among 1462 children aged 6–19 years. Linear regression, Bayesian kernel machine regression, quantile-based g-computation regression, and a generalized additive model were performed to estimate the associations. Mediation analyses were performed to investigate plausible biological pathways mediated by immune cells. Our results indicated that the phenols, parabens, and phthalates mixture was negatively related to lung function parameters. And BPA and PP were identified as important contributors to negative associations with FEV1, FVC, and PEF, with non-linear relationships observed between BPA and those outcomes. The most influential factor for a probable FEF25–75 % decline was MCNP. BPA, and MCNP had an interaction effect on FEF25–75 %. The association of PP with FVC and FEV1 has been postulated to be mediated by neutrophils and monocytes. The findings offer insights into the associations of chemical mixtures with respiratory health and the possible driving mechanism, which would be of significance in adding novel evidence of the role of peripheral immune responses, as well as calling for remediation actions to be prioritized during childhood.
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