Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

氯法齐明基岩生物信息学生物结核分枝杆菌抗药性多重耐药流出突变突变体肺结核遗传学微生物学基因医学免疫学麻风病病理

作者

Lindsay Sonnenkalb,Joshua James Carter,Andrea Spitaleri,Zamin Iqbal,Martin Hunt,Kerri M. Malone,Christian Utpatel,Daniela María Cirillo,Camilla Rodrigues,Kayzad Nilgiriwala,P. W. Fowler,Matthias Merker,Stefan Niemann,Ivan Barilar,Simone Battaglia,Emanuele Borroni,Angela Pires Brandão,Alice Brankin,Andrea Maurizio Cabibbe,Joshua A. Carter,Daniela María Cirillo,Pauline Claxton,David A. Clifton,Ted Cohen,Jorge Coronel,Derrick W. Crook,Viola Dreyer,Sarah G. Earle,Vincent Escuyer,Lucilaine Ferrazoli,P. W. Fowler,George F. Gao,Jennifer L. Gardy,Saheer E. Gharbia,Kelen Teixeira Ghisi,Arash Ghodousi,Ana Lúıza Gibertoni Cruz,Louis Grandjean,Clara Grazian,Ramona Groenheit,Jennifer L. Guthrie,Wencong He,Harald Hoffmann,Sarah Hoosdally,Martin Hunt,Zamin Iqbal,Nazir Ismail,Lisa Jarrett,Lavania Joseph,Ruwen Jou,Priti Kambli,Rukhsar Khot,Jeff Knaggs,Anastasia Koch,Donna Kohlerschmidt,Samaneh Kouchaki,Alexander S. Lachapelle,Ajit Lalvani,Simon Grandjean Lapierre,Ian F. Laurenson,Brice Letcher,Wan-Hsuan Lin,Chunfa Liu,Dongxin Liu,Kerri M. Malone,Ayan Mandal,Mikael Mansjö,Daniela Matias,Graeme Meintjes,Flávia de Freitas Mendes,Matthias Merker,Marina Mihalic,James Millard,Paolo Miotto,Nerges Mistry,David Moore,Kimberlee A. Musser,Dumisani Ngcamu,Ngoc Nhung Hoang,Stefan Niemann,Kayzad Nilgiriwala,Camus Nimmo,Nana Okozi,Rosângela Siqueira de Oliveira,Shaheed Vally Omar,Nicholas I. Paton,Tim Peto,Juliana Maíra Watanabe Pinhata,Sara Plesnik,Zully M. Puyén,Marie Sylvianne Rabodoarivelo,Niaina Rakotosamimanana,Paola M. V. Rancoita,Priti Rathod,Gillian Rodger,Camilla Rodrigues,Timothy C. Rodwell,Eaysha Roohi,David Santos-Lázaro,Sanchi Shah,Thomas A. Kohl,Grace Smith,Walter Solano,Andrea Spitaleri,Philip Supply,Utkarsha Surve,Sabira Tahseen,Nguyễn Thụy Thương Thương,Guy Thwaites,Katharina Todt,Alberto Trovato,Christian Utpatel,Annelies Van Rie,Srinivasan Vijay,Timothy M. Walker,Sarah Walker,Robin M. Warren,Jim Werngren,Maria Wijkander,Robert J. Wilkinson,Daniel J. Wilson,Penelope Wintringer,Xin Xiao Yu,Yang Yang,Yanlin Zhao,Shen-Yuan Yao,Baoli Zhu

出处

期刊：The Lancet microbe [Elsevier]
日期：2023-03-29 卷期号：4 (5): e358-e368 被引量：29

链接

thelancet.com thelancet.com hal.science hal.science handle.net ac.uk ac.uk ac.uk figshare.com figshare.com ac.uk ac.uk ac.uk nih.gov nih.govdoi.org

标识

DOI：10.1016/s2666-5247(23)00002-2

摘要

Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cross-resistant to clofazimine. To decipher bedaquiline and clofazimine resistance determinants, we combined experimental evolution, protein modelling, genome sequencing, and phenotypic data.

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Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

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