乳房
乳腺炎
金黄色葡萄球菌
免疫学
免疫系统
亚临床感染
生物
CD8型
T细胞
获得性免疫系统
免疫
微生物学
病毒学
细菌
遗传学
作者
Nisha Tucker,Patricia Cunha,Florence Gilbert,Marion Rambault,Karina Cecília Panelli Santos,Aude Remot,Pierre Germon,Pascal Rainard,Rodrigo Prado Martins
标识
DOI:10.1016/j.jri.2023.103826
摘要
T-lymphocytes are key mediators of adaptive cellular immunity and knowledge about distinct subsets of these cells in healthy and infected mammary gland secretions remains limited. In this study, we used a multiplex cytometry panel to show that staphylococcal mastitis causes the activation of CD4+, CD8+ and γδ T-cells found in bovine milk. We also highlight remarkable differences in the proportions of naïve and memory T-cells subsets found in blood and milk. These observations will contribute to a better understanding of cell-mediated immune mechanisms in the udder and to the development of new therapeutic and preventive strategies targeting mastitis.
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