利拉鲁肽
脂肪组织
脂肪细胞
血管生成
衰老
内分泌学
内科学
新生血管
生物
医学
糖尿病
2型糖尿病
作者
Run Zhang,Kangli Yao,Siyuan Chen,Xiaoxi Pan,Fang Wu,Pingjin Gao
标识
DOI:10.1016/j.bbrc.2023.02.007
摘要
Accumulating evidence suggests that Liraglutide is a favorable treatment for obese people. Obesity induces cellular senescence and accumulated senescent adipocytes in adipose tissue. However, the role of Liraglutide in adipose tissue (AT) senescence and the underlying mechanisms remain obscure. In this study, we found that HFD induces adipocyte senescence and impaired angiogenesis in AT. The deleterious effects provoked unhealthy adipose tissue remodeling and metabolic disturbance. In contrast, treatment of Liraglutide promoted weight reduction, alleviated adipose tissue senescence, and improved angiogenesis in AT. Notably, we demonstrated that Liraglutide promotes angiogenesis in AT dependent on adipocyte-derived IL-6. These findings revealed distinctive roles of Liraglutide in the regulation of adipocyte senescence and provide a therapeutic potential to obesity-associated metabolic disorders.
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