Asymmetric radical aziridination of alkenes

Metalloradical catalysis (MRC) exploits metal-centered radicals from open-shell metal complexes as one-electron catalysts for homolytic activation of substrates, generating metal-entangled organic radicals that serve as pivotal intermediates to direct the reaction pathway and stereochemical outcome of catalytic radical processes. Building on established intermolecular olefin aziridination with organic azides, recent advances have led to the development of Co(II)-based metalloradical systems that enable asymmetric N-heterobicyclization via a stepwise radical mechanism.