Associations Between Walking Speed and Gut Microbiome Composition in Older Men From the MrOS Study

微生物群 肠道微生物群 最佳步行速度 β多样性 肠道菌群 α多样性 基因组 生物 医学 内科学 生理学 生态学 免疫学 生物信息学 物种丰富度 遗传学 基因
作者
Samaneh Farsijani,Jane A. Cauley,Peggy M. Cawthon,Lisa Langsetmo,Eric Orwoll,Deborah M. Kado,Douglas P. Kiel,Anne B. Newman
出处
期刊:The Journals of Gerontology [Oxford University Press]
卷期号:79 (4)
标识
DOI:10.1093/gerona/glae030
摘要

Abstract Background Gut dysbiosis has been linked to frailty, but its association with early mobility decline is unclear. Methods First, we determined the cross-sectional associations between walking speed and the gut microbiome in 740 older men (84 ± 4 years) from the MrOS cohort with available stool samples and 400 m walking speed measured in 2014–2016. Then, we analyzed the retrospective longitudinal associations between changes in 6 m walking speed (from 2005–2006 to 2014–2016, calculated by simple linear equation) and gut microbiome composition among participants with available data (702/740). We determined gut microbiome composition by 16S sequencing and examined diversity, taxa abundance, and performed network analysis to identify differences in the gut microbiome network of fast versus slow walkers. Results Faster 400 m walking speed (m/s) was associated with greater microbiome α-diversity (R = 0.11; p = .004). The association between a slower decline in 6 m walking speed and higher α-diversity (R = 0.07; p = .054) approached borderline significance. Faster walking speed and less decline in walking speed were associated with a higher abundance of genus-level bacteria that produce short-chain fatty acids, and possess anti-inflammatory properties, including Paraprevotella, Fusicatenibacter, and Alistipes, after adjusting for potential covariates (p < .05). The gut microbiome networks of participants in the first versus last quartile of walking speed (≤0.9 vs ≥1.2 m/s) exhibited distinct characteristics, including different centrality measures (p < .05). Conclusions Our findings suggest a possible relationship between gut microbiome diversity and mobility function, as indicated by the associations between faster walking speed and less decline in walking speed over 10 years with higher gut microbiome diversity in older men.

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