Enzalutamide and Leuprolide Acetate in Non-Metastatic Hormone-Sensitive Prostate Cancer: The Sooner the Better?

恩扎鲁胺 医学 前列腺癌 醋酸阿比特龙酯 肿瘤科 雄激素剥夺疗法 内科学 癌症 妇科 泌尿科 雄激素受体
作者
Emilio Francesco Giunta,Lorenzo Gasperoni,Ugo De Giorgi
出处
期刊:Future Oncology [Future Medicine]
卷期号:20 (4): 163-166 被引量:1
标识
DOI:10.2217/fon-2023-1019
摘要

Future OncologyVol. 20, No. 4 EditorialEnzalutamide and leuprolide acetate in non-metastatic hormone-sensitive prostate cancer: the sooner the better?Emilio Francesco Giunta, Lorenzo Gasperoni & Ugo De GiorgiEmilio Francesco Giunta https://orcid.org/0000-0002-5383-4469Department of Medical Oncology, Meldola, Italy, Lorenzo GasperoniOncological Pharmacy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy & Ugo De Giorgi *Author for correspondence: Tel.: +39 0543 739 100; https://orcid.org/0000-0001-7520-2908Department of Medical Oncology, Meldola, ItalyPublished Online:7 Feb 2024https://doi.org/10.2217/fon-2023-1019AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: androgen deprivation therapycastrationenzalutamidepatient-reported outcomesprostate cancersafetyReferences1. Van den Broeck T, van den Bergh RCN, Briers E et al. Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations. Eur. Urol. Focus 6(2), 231–234 (2020).MedlineGoogle Scholar2. Freedland SJ, De Giorgi U, Gleave M et al. A Phase III randomised study of enzalutamide plus leuprolide and enzalutamide monotherapy in high-risk non-metastatic hormone-sensitive prostate cancer with rising PSA after local therapy: EMBARK study design. BMJ Open. 11(8), e046588 (2021).MedlineGoogle Scholar3. Freedland SJ, de Almeida Luz M, De Giorgi U et al. Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer. N. Engl. J. Med. 389(16), 1453–1465 (2023).Medline CASGoogle Scholar4. https://www.drugs.com/history/xtandi.html (accessed on 5th November 2023).Google Scholar5. Scher HI, Fizazi K, Saad F et al. AFFIRM Investigators. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 367(13), 1187–1197 (2012).Medline CASGoogle Scholar6. Payne H, Robinson A, Rappe B et al. European, prospective, observational study of enzalutamide in patients with metastatic castration-resistant prostate cancer: PREMISE. Int. J. Cancer 150(5), 837–846 (2022).Medline CASGoogle Scholar7. Davis ID, Martin AJ, Stockler MR et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N. Engl. J. Med. 381(2), 121–131 (2019).Medline CASGoogle Scholar8. Sternberg CN, Fizazi K, Saad F et al. Enzalutamide and survival in nonmetastatic, castration-resistant prostate cancer. N. Engl. J. Med. 382(23), 2197–2206 (2020).Medline CASGoogle Scholar9. Freedland SJ, Gleave M, De Giorgi U et al. Enzalutamide and Quality of Life in Biochemically Recurrent Prostate Cancer. NEJM Evid. 2(12), (2023). Epub ahead of print 21 October 2023 doi: 10.1056/EVIDoa2300251MedlineGoogle Scholar10. De Giorgi U, Freedland SJ, Gleave ME et al. Enzalutamide (enza) monotherapy for the treatment (tx) of prostate cancer with high-risk biochemical recurrence (BCR): EMBARK secondary endpoints. Ann. Oncol. 34, S960–S961 (2023).MedlineGoogle Scholar11. Freedland SJ, Gleave ME, De Giorgi U et al. Treatment (tx) of high-risk biochemically recurrent prostate cancer with enzalutamide (enza) in combination with leuprolide acetate (LA): Secondary endpoints from EMBARK. Ann. Oncol. 34, S961 (2023).Google Scholar12. Andriole GL. The impact of prostate cancer and hormonal therapy on bone. Rev. Urol. 11(4), 185–189 (2009).MedlineGoogle Scholar13. Mottet N, van den Bergh RCN, Briers E et al. EAU-EANM-ESTRO-ESURSIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur. Urol. 79(2), 243–262 (2021).Medline CASGoogle Scholar14. Caroli P, Sandler I, Matteucci F et al. 68Ga-PSMA PET/CT in patients with recurrent prostate cancer after radical treatment: prospective results in 314 patients. Eur. J. Nucl. Med. Mol. Imaging 45(12), 2035–2044 (2018).Medline CASGoogle Scholar15. Linder S, van der Poel HG, Bergman AM et al. Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond. Endocr. Relat. Cancer 26(1), R31–R52 (2018).MedlineGoogle Scholar16. Salvi S, Casadio V, Conteduca V et al. Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer. Oncotarget 7(25), 37839–37845 (2016).MedlineGoogle Scholar17. Conteduca V, Jayaram A, Romero-Laorden N et al. Plasma androgen receptor and docetaxel for metastatic castration-resistant prostate cancer. Eur. Urol. 75(3), 368–373 (2019).Medline CASGoogle Scholar18. De Giorgi U, Sansovini M, Severi S et al. Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: results of a Phase 2 trial. Br. J. Cancer 125(9), 1226–1232 (2021).MedlineGoogle Scholar19. de Jong AC, Danyi A, van Riet J et al. Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning. Nat. Commun. 14(1), 1968 (2023).Medline CASGoogle Scholar20. Grypari IM, Tzelepi V, Gyftopoulos K. DNA damage repair pathways in prostate cancer: a narrative review of molecular mechanisms, emerging biomarkers and therapeutic targets in precision oncology. Int. J. Mol. Sci. 24(14), 11418 (2023).Medline CASGoogle ScholarFiguresReferencesRelatedDetails Vol. 20, No. 4 STAY CONNECTED Metrics Downloaded 65 times History Received 14 April 2023 Accepted 22 January 2024 Published online 7 February 2024 Published in print February 2024 Information© 2024 Expert Publishing Medicine Ltd trading as Taylor & FrancisKeywordsandrogen deprivation therapycastrationenzalutamidepatient-reported outcomesprostate cancersafetyFinancial disclosureThe authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
SCL发布了新的文献求助10
刚刚
嘿嘿发布了新的文献求助10
1秒前
年糕发布了新的文献求助10
1秒前
1秒前
2秒前
2秒前
刘的花完成签到,获得积分10
2秒前
HJJHJH发布了新的文献求助10
2秒前
所所应助ycy采纳,获得10
4秒前
所所应助辉辉采纳,获得10
4秒前
桐桐应助一烟尘采纳,获得10
4秒前
5秒前
好好学习完成签到,获得积分20
5秒前
小新发布了新的文献求助10
5秒前
机智以筠发布了新的文献求助10
5秒前
Wendy完成签到,获得积分10
5秒前
5秒前
丘比特应助Liiipan采纳,获得10
5秒前
YHX9910发布了新的文献求助10
6秒前
Lucas应助清爽含灵采纳,获得10
6秒前
遥不可及发布了新的文献求助10
7秒前
思源应助xin采纳,获得10
7秒前
圆圆完成签到 ,获得积分10
8秒前
8秒前
英姑应助努力采纳,获得10
8秒前
tangbaotian完成签到,获得积分10
8秒前
8秒前
duan完成签到 ,获得积分10
8秒前
8秒前
vic完成签到,获得积分10
8秒前
踏实嚣发布了新的文献求助10
8秒前
zhangliangfu完成签到,获得积分10
9秒前
9秒前
畅快的刚完成签到,获得积分10
9秒前
W昂发布了新的文献求助10
10秒前
JYL发布了新的文献求助10
10秒前
聪慧的完成签到,获得积分10
11秒前
11秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
List of 1,091 Public Pension Profiles by Region 1561
Specialist Periodical Reports - Organometallic Chemistry Organometallic Chemistry: Volume 46 1000
Current Trends in Drug Discovery, Development and Delivery (CTD4-2022) 800
Foregrounding Marking Shift in Sundanese Written Narrative Segments 600
Holistic Discourse Analysis 600
Beyond the sentence: discourse and sentential form / edited by Jessica R. Wirth 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 遗传学 催化作用 冶金 量子力学 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 5521079
求助须知:如何正确求助?哪些是违规求助? 4612571
关于积分的说明 14534355
捐赠科研通 4550094
什么是DOI,文献DOI怎么找? 2493467
邀请新用户注册赠送积分活动 1474588
关于科研通互助平台的介绍 1446154