Enzalutamide and Leuprolide Acetate in Non-Metastatic Hormone-Sensitive Prostate Cancer: The Sooner the Better?

恩扎鲁胺 医学 前列腺癌 醋酸阿比特龙酯 肿瘤科 雄激素剥夺疗法 内科学 癌症 妇科 泌尿科 雄激素受体
作者
Emilio Francesco Giunta,Lorenzo Gasperoni,Ugo De Giorgi
出处
期刊:Future Oncology [Future Medicine]
卷期号:20 (4): 163-166 被引量:1
标识
DOI:10.2217/fon-2023-1019
摘要

Future OncologyVol. 20, No. 4 EditorialEnzalutamide and leuprolide acetate in non-metastatic hormone-sensitive prostate cancer: the sooner the better?Emilio Francesco Giunta, Lorenzo Gasperoni & Ugo De GiorgiEmilio Francesco Giunta https://orcid.org/0000-0002-5383-4469Department of Medical Oncology, Meldola, Italy, Lorenzo GasperoniOncological Pharmacy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy & Ugo De Giorgi *Author for correspondence: Tel.: +39 0543 739 100; https://orcid.org/0000-0001-7520-2908Department of Medical Oncology, Meldola, ItalyPublished Online:7 Feb 2024https://doi.org/10.2217/fon-2023-1019AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: androgen deprivation therapycastrationenzalutamidepatient-reported outcomesprostate cancersafetyReferences1. Van den Broeck T, van den Bergh RCN, Briers E et al. Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations. Eur. Urol. Focus 6(2), 231–234 (2020).MedlineGoogle Scholar2. Freedland SJ, De Giorgi U, Gleave M et al. A Phase III randomised study of enzalutamide plus leuprolide and enzalutamide monotherapy in high-risk non-metastatic hormone-sensitive prostate cancer with rising PSA after local therapy: EMBARK study design. BMJ Open. 11(8), e046588 (2021).MedlineGoogle Scholar3. Freedland SJ, de Almeida Luz M, De Giorgi U et al. Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer. N. Engl. J. Med. 389(16), 1453–1465 (2023).Medline CASGoogle Scholar4. https://www.drugs.com/history/xtandi.html (accessed on 5th November 2023).Google Scholar5. Scher HI, Fizazi K, Saad F et al. AFFIRM Investigators. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 367(13), 1187–1197 (2012).Medline CASGoogle Scholar6. Payne H, Robinson A, Rappe B et al. European, prospective, observational study of enzalutamide in patients with metastatic castration-resistant prostate cancer: PREMISE. Int. J. Cancer 150(5), 837–846 (2022).Medline CASGoogle Scholar7. Davis ID, Martin AJ, Stockler MR et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N. Engl. J. Med. 381(2), 121–131 (2019).Medline CASGoogle Scholar8. Sternberg CN, Fizazi K, Saad F et al. Enzalutamide and survival in nonmetastatic, castration-resistant prostate cancer. N. Engl. J. Med. 382(23), 2197–2206 (2020).Medline CASGoogle Scholar9. Freedland SJ, Gleave M, De Giorgi U et al. Enzalutamide and Quality of Life in Biochemically Recurrent Prostate Cancer. NEJM Evid. 2(12), (2023). Epub ahead of print 21 October 2023 doi: 10.1056/EVIDoa2300251MedlineGoogle Scholar10. De Giorgi U, Freedland SJ, Gleave ME et al. Enzalutamide (enza) monotherapy for the treatment (tx) of prostate cancer with high-risk biochemical recurrence (BCR): EMBARK secondary endpoints. Ann. Oncol. 34, S960–S961 (2023).MedlineGoogle Scholar11. Freedland SJ, Gleave ME, De Giorgi U et al. Treatment (tx) of high-risk biochemically recurrent prostate cancer with enzalutamide (enza) in combination with leuprolide acetate (LA): Secondary endpoints from EMBARK. Ann. Oncol. 34, S961 (2023).Google Scholar12. Andriole GL. The impact of prostate cancer and hormonal therapy on bone. Rev. Urol. 11(4), 185–189 (2009).MedlineGoogle Scholar13. Mottet N, van den Bergh RCN, Briers E et al. EAU-EANM-ESTRO-ESURSIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur. Urol. 79(2), 243–262 (2021).Medline CASGoogle Scholar14. Caroli P, Sandler I, Matteucci F et al. 68Ga-PSMA PET/CT in patients with recurrent prostate cancer after radical treatment: prospective results in 314 patients. Eur. J. Nucl. Med. Mol. Imaging 45(12), 2035–2044 (2018).Medline CASGoogle Scholar15. Linder S, van der Poel HG, Bergman AM et al. Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond. Endocr. Relat. Cancer 26(1), R31–R52 (2018).MedlineGoogle Scholar16. Salvi S, Casadio V, Conteduca V et al. Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer. Oncotarget 7(25), 37839–37845 (2016).MedlineGoogle Scholar17. Conteduca V, Jayaram A, Romero-Laorden N et al. Plasma androgen receptor and docetaxel for metastatic castration-resistant prostate cancer. Eur. Urol. 75(3), 368–373 (2019).Medline CASGoogle Scholar18. De Giorgi U, Sansovini M, Severi S et al. Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: results of a Phase 2 trial. Br. J. Cancer 125(9), 1226–1232 (2021).MedlineGoogle Scholar19. de Jong AC, Danyi A, van Riet J et al. Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning. Nat. Commun. 14(1), 1968 (2023).Medline CASGoogle Scholar20. Grypari IM, Tzelepi V, Gyftopoulos K. DNA damage repair pathways in prostate cancer: a narrative review of molecular mechanisms, emerging biomarkers and therapeutic targets in precision oncology. Int. J. Mol. Sci. 24(14), 11418 (2023).Medline CASGoogle ScholarFiguresReferencesRelatedDetails Vol. 20, No. 4 STAY CONNECTED Metrics Downloaded 65 times History Received 14 April 2023 Accepted 22 January 2024 Published online 7 February 2024 Published in print February 2024 Information© 2024 Expert Publishing Medicine Ltd trading as Taylor & FrancisKeywordsandrogen deprivation therapycastrationenzalutamidepatient-reported outcomesprostate cancersafetyFinancial disclosureThe authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
rr12完成签到,获得积分10
刚刚
在水一方应助Litoivda采纳,获得10
1秒前
梦中学习完成签到 ,获得积分10
2秒前
Cherish完成签到,获得积分10
3秒前
crystal完成签到 ,获得积分10
3秒前
会尽快苍发布了新的文献求助10
4秒前
4秒前
蜗牛完成签到,获得积分10
6秒前
奇异果熊猫人完成签到,获得积分10
7秒前
要减肥香水完成签到,获得积分10
7秒前
hoshiii完成签到,获得积分10
8秒前
冯冯完成签到 ,获得积分10
8秒前
科研通AI6.3应助wood采纳,获得10
8秒前
8秒前
ding应助请知识进脑子采纳,获得10
8秒前
CC完成签到 ,获得积分10
8秒前
自信友梅完成签到 ,获得积分10
9秒前
lucky小蘑菇完成签到,获得积分10
10秒前
1109关注了科研通微信公众号
10秒前
tzy发布了新的文献求助20
10秒前
Jiygua完成签到,获得积分10
10秒前
huang完成签到,获得积分10
11秒前
研友_O8Wz4Z完成签到,获得积分10
12秒前
重要板凳完成签到 ,获得积分10
12秒前
ada完成签到,获得积分10
12秒前
恒星完成签到,获得积分10
12秒前
Inter09完成签到,获得积分10
13秒前
空空完成签到,获得积分10
13秒前
13秒前
YQT完成签到,获得积分10
14秒前
Julia发布了新的文献求助50
14秒前
12334完成签到,获得积分10
15秒前
小蒋完成签到 ,获得积分10
15秒前
科研通AI6.4应助liuxiaomeng采纳,获得10
15秒前
小猪发布了新的文献求助10
15秒前
等待的大炮完成签到,获得积分10
15秒前
请知识进脑子完成签到,获得积分10
16秒前
贴贴完成签到,获得积分10
16秒前
汉堡包应助hetao286采纳,获得10
17秒前
rainbow完成签到,获得积分10
17秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Common Foundations of American and East Asian Modernisation: From Alexander Hamilton to Junichero Koizumi 1500
Weaponeering: An Introduction Fourth Edition, Volume 1 1000
Advanced Weaponeering Fourth Edition, Volume 2 1000
悉尼大学博士学位论文,题目:Modelling and testing of one-sided stitched laminated composites. 作者:Kristopher P. Plain 700
Matrix Methods in Data Mining and Pattern Recognition Second Edition 610
Curating Socialism: A Handbook of International Art Exhibitions 1947-1989 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7513999
求助须知:如何正确求助?哪些是违规求助? 9102402
关于积分的说明 19428151
捐赠科研通 7119594
什么是DOI,文献DOI怎么找? 3253370
关于科研通互助平台的介绍 2422187
邀请新用户注册赠送积分活动 2239932