平衡
细胞内
铜代谢
铜缺乏
铁稳态
线粒体
细胞代谢
神经科学
细胞生物学
新陈代谢
神经退行性变
细胞代谢
医学
铜
生物
疾病
化学
生物化学
病理
有机化学
作者
Xiao-Xia Ban,Hao Wan,Xinxing Wan,Ya-ting Tan,Xi-Min Hu,Hiroshi Ban,Xinyu Chen,Kun Huang,Qí Zhāng,Kun Xiong
标识
DOI:10.1007/s11596-024-2832-z
摘要
Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the human body maintains copper homeostasis. Copper deficiency or excess can adversely affect cellular function. Therefore, copper homeostasis is stringently regulated. Recent studies suggest that copper can trigger a specific form of cell death, namely, cuproptosis, which is triggered by excessive levels of intracellular copper. Cuproptosis induces the aggregation of mitochondrial lipoylated proteins, and the loss of iron-sulfur cluster proteins. In neurodegenerative diseases, the pathogenesis and progression of neurological disorders are linked to copper homeostasis. This review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative diseases. This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI