免疫疗法
肿瘤微环境
癌症研究
肝细胞癌
免疫系统
免疫学
淋巴因子激活杀伤细胞
自然杀伤细胞
医学
白细胞介素12
过继性细胞移植
白细胞介素21
T细胞
生物
细胞毒性
细胞毒性T细胞
生物化学
体外
作者
Xinyue Zhu,Yu‐Fu Zhou,Shiguo Zhu
出处
期刊:PubMed
日期:2024-01-01
卷期号:40 (1): 80-88
摘要
Hepatocellular carcinoma (HCC) is well characterized as a heterogeneous disease. Its late-stage diagnosis and chemotherapy resistance make it one of the refractory tumors in China. Natural killer (NK) cells play a significant role in immune surveillance. However, NK cells become dysfunctional in the progression of HCC, leading to tumor immune escape. This article reviews the recent progress on different strategies of NK cell-based immunotherapy in treating HCC, including direct adoptive NK cell transfer, gene engineering in NK cell, NK cell receptor targeting, immunosuppressive microenvironment modification, and tumor toxicity enhancement by cytokines or traditional Chinese medicine. These NK cell-based strategies have shown promising therapeutic potential.
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