作者
Ya Luo,Xianmei Qi,Zhenxi Zhang,Jiawei Zhang,Bolun Li,Ting Shu,Xiaona Li,Huiyuan Hu,Jinqiu Li,Qihao Tang,Yitian Zhou,Mingyao Wang,Tianfei Fan,Wenjun Guo,Ying Liu,J. Zhang,Junling Pang,Peiran Yang,Ran Gao,Wenhui Chen,Chen Yan,Yanjiang Xing,Wenjing Du,Jing Wang,Chen Wang
摘要
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, the underlying cellular and molecular mechanisms are not fully understood. In this study, we focused on ME1 (malic enzyme 1), a key enzyme linking glycolysis to the tricarboxylic acid cycle. We aimed to determine the role and mechanistic action of ME1 in PH.