Enzyme‐Particle Complexes Facilitate Pickering Interfacial Biocatalysis

Pickering interfacial biocatalysis (PIB), where biocatalysts stabilize emulsions through carrier coupling or polymer grafting, has emerged as a powerful platform for organic synthesis due to its ability to accommodate water‐insoluble substrates within enzymatic cascade reactions. PIB provides a large interfacial area for two‐phase reactions, reducing diffusional resistance and enhancing transformation efficiency. The performance of PIB relies heavily on enzyme‐particle conjugates, which serve a dual function: stabilizing the emulsion and acting as the active biocatalysts in the system. In this Concept, we discuss the latest advancements, current challenges, and future directions in the development of protein‐particle conjugates for PIB.