明胶
壳聚糖
傅里叶变换红外光谱
生物材料
核化学
粘液
聚合物
电子顺磁共振
肿胀 的
材料科学
生物高聚物
天然聚合物
化学
高分子化学
化学工程
纳米技术
有机化学
复合材料
植物
核磁共振
物理
工程类
生物
作者
Samira Jebahi,Bessaleh Salma,Amel Raouafi,Hajji Sawsen,Hassib Keskes,Mustpha Hidouri
标识
DOI:10.1177/03913988221114158
摘要
The development of natural-based wound dressings is of great interest in the field of skin tissue engineering. Herein, different bioactive molecules such as gelatin (GEL), chitosan (CH) and mucilage (MU) were used to prepare a wound dressing. The physico-chemical and biological characterizations occurring after γ-irradiation were investigated. Results showed that Electron Paramagnetic Resonance (EPR) spectroscopy of un-irradiated GEL-CH-MU biomaterial showed two paramagnetic centers which correspond to g = 1.89 and g = 2.033. A generated new active center appeared at g = 2.003 at 25 kGy due to the interactions of gamma rays with the polymer chain creating signals at the absorbing functional groups. X-ray diffraction (XRD) spectra preserved the semi-crystalline structures between a range of 2θ (5° and 45°). Fourier Transform Infrared spectroscopy (FTIR) revealed that the initiation of cross linking phenomena. Moreover, γ-rays significantly increased antioxidant activity (9.1 ± 0.07%, p < 0.05) and exhibited a high anti-inflammatory activity (70%) at 25 kGy. Significant antibacterial activities in vitro liquid medium was observed. In addition GEL-CH-MU dressing exhibited high hemocompatibility. Conducted investigations state that such innovative dressing natural-based polymers for advanced wound care may be considered as useful for biomedical purposes.
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