LncRNA TUG1 regulates autophagy in atherosclerosis by sponging miR-145-5p

Zhang et al. [1] reported that miR-145-5p is downregulated in blood and arteries specimens of patients with coronary stenosis. CaMKIIδ is promoted by the downregulation of miR-145-5p and then activating autophagy in human aortic vascular smooth muscle cells through the AMPK/mTOR/ULK1 signal pathway to regulate atherosclerosis progress. This finding may recognize a novel target of miR-145-5p in clinical therapy of atherosclerosis, whereas the mechanisms of miR-145-5p lowly expression in myocardial infarction need further exploration.