A multidimensional pan‐cancer analysis of DCAF13 and its protumorigenic effect in lung adenocarcinoma

肺癌 腺癌 癌症 内科学 医学
作者
Shan Wei,Kaining Lu,Jing Xing,Wanjun Yu
出处
期刊:The FASEB Journal [Wiley]
卷期号:37 (4) 被引量:5
标识
DOI:10.1096/fj.202201022rrr
摘要

Abstract DCAF13 is a substrate recognition protein in the ubiquitin‐proteasome system with oncogenic effects in several malignant tumors. However, it is unclear that the relationship between DCAF13 expression pattern and prognosis across different cancer types. Also unknown is the biological function or effects on the immune microenvironment of DCAF13. In this study, we parsed multiple public databases to explore the potential tumorigenic actions of DCAF13 , including correlations with prognosis, microsatellite instability (MSI), tumor mutational burden (TMB), immune checkpoint genes, immune cell infiltration, and immunotherapy response in pan‐cancer. Moreover, we validated DCAF13 expression in a tissue microarray by immunohistochemistry and investigate its effects in vitro and in vivo. The results showed that DCAF13 was upregulated in 17 cancer types and correlated with poor prognosis in many cancers. Also, the correlation between DCAF13 and TMB was found in 14 cancers as well as MSI in nine. The expression level of DCAF13 was found to be notably correlated with immune cell infiltration, showing a negative correlation with CD4 T cell infiltration and a positive correlation with neutrophil infiltration. The oncogene DCAF13 expression was shown to have a positive correlation with CD274 or ADORA2A and negative correlation with VSIR , TNFRSF4 , or TNFRSF14 across large subsets of human cancers. Finally, we observed that DCAF13 was highly expressed in a tissue microarray of lung cancer. In immunocompromised mouse models, xenograft growth of human lung cancer cells was significantly inhibited by DCAF13 knockdown. Our results highlighted the value of DCAF13 as a promising independent predictor of poor prognosis through numerous biological processes. High DCAF13 expression often predicts suppressive immune microenvironment and immunotherapy resistance in a pan‐cancer context.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
岩下松风完成签到,获得积分10
1秒前
2秒前
不攻自破发布了新的文献求助10
2秒前
领导范儿应助没天赋采纳,获得10
2秒前
2秒前
午见千山应助科研通管家采纳,获得10
3秒前
黎li发布了新的文献求助10
3秒前
彭于晏应助科研通管家采纳,获得10
3秒前
科目三应助科研通管家采纳,获得10
3秒前
3秒前
背后雨柏完成签到 ,获得积分10
3秒前
云中应助左丘以云采纳,获得20
4秒前
fangfang发布了新的文献求助10
4秒前
4秒前
rui完成签到 ,获得积分10
5秒前
笑点低的发箍完成签到 ,获得积分10
5秒前
研路漫漫给研路漫漫的求助进行了留言
6秒前
博慧发布了新的文献求助10
7秒前
hzz完成签到,获得积分10
7秒前
文献求助完成签到,获得积分10
7秒前
luo完成签到,获得积分10
7秒前
RUI完成签到,获得积分10
7秒前
aron完成签到,获得积分10
7秒前
酷酷李可爱婕完成签到 ,获得积分10
8秒前
加油完成签到,获得积分10
8秒前
8秒前
隐形的谷槐完成签到 ,获得积分10
8秒前
年轻真好啊完成签到,获得积分10
9秒前
加勒比发布了新的文献求助10
9秒前
10秒前
10秒前
木木木木完成签到,获得积分10
11秒前
tuanhust完成签到,获得积分0
11秒前
Profeto应助张英俊采纳,获得10
11秒前
shiyin完成签到,获得积分10
12秒前
kajimi完成签到,获得积分10
12秒前
kndfsfmf完成签到,获得积分10
12秒前
omitoo发布了新的文献求助10
12秒前
群山完成签到 ,获得积分10
12秒前
12秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009325
求助须知:如何正确求助?哪些是违规求助? 3549162
关于积分的说明 11301105
捐赠科研通 3283572
什么是DOI,文献DOI怎么找? 1810370
邀请新用户注册赠送积分活动 886205
科研通“疑难数据库(出版商)”最低求助积分说明 811301