医学
神经保护
间充质干细胞
干细胞疗法
脑病
缺氧缺血性脑病
干细胞
移植
神经科学
生物信息学
重症监护医学
病理
药理学
外科
内科学
生物
遗传学
作者
So Yoon Ahn,Yun Sil Chang,Won Soon Park
标识
DOI:10.1016/j.semperi.2023.151726
摘要
Neonatal brain injury resulting from various intractable disorders including intraventricular hemorrhage and hypoxic ischemic encephalopathy still remains a major cause of mortality and morbidities with few effective treatments. Recent preclinical research results showing the pleiotropic neuroprotective effects of stem cell therapy, specifically mesenchymal stem cells (MSCs), suggest that MSCs transplantation might be a promising new therapeutic modality for neuroprotection against the currently intractable and devastating neonatal brain injury with complex multifactorial etiology. This review summarizes recent advances in preclinical stem cell research for treating neonatal brain injury with a focus on the important issues including the mechanism of neuroprotection, and determining the ideal cell source, route, timing and dose of MSCs transplantation.
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