清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization

医学 谵妄 痴呆 认知 认知障碍 认知功能衰退 2019年冠状病毒病(COVID-19) 儿科 疾病 内科学 精神科 传染病(医学专业)
作者
Natália Gomes Gonçalves,Márlon Juliano Romero Aliberti,Laiss Bertola,Thiago Junqueira Avelino‐Silva,Murilo Bacchini Dias,Daniel Apolinário,Geraldo F. Busatto,Orestes Vicente Forlenza,Ricardo Nitríni,Sônia Maria Dozzi Brucki,André R. Brunoni,Kallene Summer Moreira Vidal,Wilson Jacob Filho,Cláudia Kimie Suemoto
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:19 (9): 3771-3782 被引量:13
标识
DOI:10.1002/alz.12993
摘要

Abstract Introduction Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, associations between post‐hospital discharge risk factors and cognitive trajectories have not been explored. Methods A total of 1105 adults (mean age ± SD 64.9 ± 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID‐19) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis. Results Three groups of cognitive trajectories were observed during the follow‐up: no cognitive impairment, initial short‐term cognitive impairment, and long‐term cognitive impairment. Predictors of cognitive decline after COVID‐19 were older age ( β = −0.013, 95% CI = −0.023;−0.003), female sex ( β = −0.230, 95% CI = −0.413;−0.047), previous dementia diagnosis or substantial memory complaints ( β = −0.606, 95% CI = −0.877;−0.335), frailty before hospitalization ( β = −0.191, 95% CI = −0.264;−0.119), higher platelet count ( β = −0.101, 95% CI = −0.185;−0.018), and delirium ( β = −0.483, 95% CI = −0.724;−0.244). Post‐discharge predictors included hospital readmissions and frailty. Discussion Cognitive impairment was common and the patterns of cognitive trajectories depended on sociodemographic, in‐hospital, and post‐hospitalization predictors. Highlights Cognitive impairment after coronavirus disease 2019 (COVID‐19) hospital discharge was associated with higher age, less education, delirium during hospitalization, a higher number of hospitalizations post discharge, and frailty before and after hospitalization. Frequent cognitive evaluations for 12‐month post‐COVID‐19 hospitalization showed three possible cognitive trajectories: no cognitive impairment, initial short‐term impairment, and long‐term impairment. This study highlights the importance of frequent cognitive testing to determine patterns of COVID‐19 cognitive impairment, given the high frequency of incident cognitive impairment 1 year after hospitalization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
淡然一德完成签到,获得积分10
13秒前
清秀灵薇完成签到,获得积分10
16秒前
mathmotive完成签到,获得积分20
19秒前
丁老三完成签到 ,获得积分10
19秒前
fei完成签到 ,获得积分10
33秒前
三个气的大门完成签到 ,获得积分10
41秒前
幽默滑板完成签到,获得积分10
48秒前
郭俊秀完成签到 ,获得积分10
56秒前
胡可完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
梵莫发布了新的文献求助10
1分钟前
Wen完成签到 ,获得积分10
1分钟前
云下完成签到 ,获得积分10
1分钟前
aaiirrii完成签到,获得积分10
1分钟前
浚稚完成签到 ,获得积分10
2分钟前
Sandy应助土豆··采纳,获得20
2分钟前
WittingGU完成签到,获得积分0
2分钟前
仁和完成签到 ,获得积分10
2分钟前
2分钟前
噼里啪啦完成签到 ,获得积分10
3分钟前
小龙仔123完成签到 ,获得积分20
3分钟前
大水完成签到 ,获得积分10
3分钟前
雪山飞龙发布了新的文献求助10
3分钟前
通科研完成签到 ,获得积分10
3分钟前
aq22完成签到 ,获得积分10
3分钟前
xdd完成签到 ,获得积分10
3分钟前
风华完成签到,获得积分10
3分钟前
3分钟前
herpes完成签到 ,获得积分10
3分钟前
GGBond完成签到 ,获得积分10
4分钟前
livinglast完成签到 ,获得积分10
4分钟前
4分钟前
Rondab应助雪山飞龙采纳,获得10
4分钟前
梵莫完成签到,获得积分10
4分钟前
sherry完成签到 ,获得积分10
4分钟前
Young完成签到 ,获得积分10
4分钟前
xue完成签到 ,获得积分10
4分钟前
丘比特应助科研通管家采纳,获得10
4分钟前
林利芳完成签到 ,获得积分0
5分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968521
求助须知:如何正确求助?哪些是违规求助? 3513341
关于积分的说明 11167298
捐赠科研通 3248700
什么是DOI,文献DOI怎么找? 1794434
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804664