Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization

医学 谵妄 痴呆 认知 认知障碍 认知功能衰退 2019年冠状病毒病(COVID-19) 儿科 疾病 内科学 精神科 传染病(医学专业)
作者
Natália Gomes Gonçalves,Márlon Juliano Romero Aliberti,Laiss Bertola,Thiago Junqueira Avelino‐Silva,Murilo Bacchini Dias,Daniel Apolinário,Geraldo F. Busatto,Orestes Vicente Forlenza,Ricardo Nitríni,Sônia Maria Dozzi Brucki,André R. Brunoni,Kallene Summer Moreira Vidal,Wilson Jacob Filho,Cláudia Kimie Suemoto
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:19 (9): 3771-3782 被引量:13
标识
DOI:10.1002/alz.12993
摘要

Abstract Introduction Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, associations between post‐hospital discharge risk factors and cognitive trajectories have not been explored. Methods A total of 1105 adults (mean age ± SD 64.9 ± 9.9 years, 44% women, 63% White) with severe coronavirus disease 2019 (COVID‐19) were evaluated for cognitive function 1 year after hospital discharge. Scores from cognitive tests were harmonized, and clusters of cognitive impairment were defined using sequential analysis. Results Three groups of cognitive trajectories were observed during the follow‐up: no cognitive impairment, initial short‐term cognitive impairment, and long‐term cognitive impairment. Predictors of cognitive decline after COVID‐19 were older age ( β = −0.013, 95% CI = −0.023;−0.003), female sex ( β = −0.230, 95% CI = −0.413;−0.047), previous dementia diagnosis or substantial memory complaints ( β = −0.606, 95% CI = −0.877;−0.335), frailty before hospitalization ( β = −0.191, 95% CI = −0.264;−0.119), higher platelet count ( β = −0.101, 95% CI = −0.185;−0.018), and delirium ( β = −0.483, 95% CI = −0.724;−0.244). Post‐discharge predictors included hospital readmissions and frailty. Discussion Cognitive impairment was common and the patterns of cognitive trajectories depended on sociodemographic, in‐hospital, and post‐hospitalization predictors. Highlights Cognitive impairment after coronavirus disease 2019 (COVID‐19) hospital discharge was associated with higher age, less education, delirium during hospitalization, a higher number of hospitalizations post discharge, and frailty before and after hospitalization. Frequent cognitive evaluations for 12‐month post‐COVID‐19 hospitalization showed three possible cognitive trajectories: no cognitive impairment, initial short‐term impairment, and long‐term impairment. This study highlights the importance of frequent cognitive testing to determine patterns of COVID‐19 cognitive impairment, given the high frequency of incident cognitive impairment 1 year after hospitalization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
121314wld完成签到,获得积分10
刚刚
wjx发布了新的文献求助10
1秒前
weifeng完成签到,获得积分10
1秒前
叁月完成签到,获得积分10
1秒前
1秒前
2秒前
我淦完成签到 ,获得积分10
2秒前
2秒前
2秒前
2549360318完成签到,获得积分10
2秒前
2秒前
2秒前
hang发布了新的文献求助10
3秒前
4秒前
dwct发布了新的文献求助10
4秒前
weifeng发布了新的文献求助10
4秒前
4秒前
lubo完成签到,获得积分10
4秒前
4秒前
爰采唐矣发布了新的文献求助10
4秒前
5秒前
5秒前
善学以致用应助小芭乐采纳,获得10
5秒前
拂晓发布了新的文献求助10
5秒前
SciGPT应助feihua采纳,获得10
6秒前
6秒前
6秒前
dongdong发布了新的文献求助10
7秒前
7秒前
sdl发布了新的文献求助10
7秒前
7秒前
沉静丹寒发布了新的文献求助10
8秒前
泽丶完成签到,获得积分10
8秒前
AI_S发布了新的文献求助10
8秒前
情怀应助周常通采纳,获得10
9秒前
知栀完成签到 ,获得积分10
10秒前
lubo发布了新的文献求助10
10秒前
10秒前
SUN发布了新的文献求助10
10秒前
10秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974943
求助须知:如何正确求助?哪些是违规求助? 3519467
关于积分的说明 11198482
捐赠科研通 3255728
什么是DOI,文献DOI怎么找? 1797904
邀请新用户注册赠送积分活动 877261
科研通“疑难数据库(出版商)”最低求助积分说明 806224