神经科学
体感系统
仿形(计算机编程)
电池类型
神经细胞
转录组
神经元
基因表达谱
背
生物
计算生物学
细胞
计算机科学
基因
基因表达
解剖
遗传学
操作系统
作者
Kaikai Wang,Bing Cai,Yuran Song,Yan Chen,Xu Zhang
标识
DOI:10.1016/j.tins.2023.05.005
摘要
Abstract
Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the evaluation criteria used in previous studies to classify DRG neurons varied, which presents difficulties in determining the various types of DRG neurons. In this review, we aim to integrate findings from previous transcriptomic studies of the DRG. We first briefly introduce the history of DRG-neuron cell-type profiling, and discuss the advantages and disadvantages of different scRNA-seq methods. We then examine the classification of DRG neurons based on single-cell profiling under physiological and pathological conditions. Finally, we propose further studies on the somatosensory system at the molecular, cellular, and neural network levels.
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