The Safety of Human Embryos Following Long-Term Cryopreservation (≥ 6 Years) on Vitrification

玻璃化 低温保存 流产 胚胎移植 活产 怀孕 男科 胚胎冷冻保存 胚胎 医学 妊娠率 人绒毛膜促性腺激素 妇科 倾向得分匹配 辅助生殖技术 产科 生物 不育 外科 遗传学 细胞生物学
作者
Hui He,Rui Jiang,Xinling Ren,Lei Jin,Yaping Jiang
出处
期刊:Cryo letters 卷期号:44 (3): 178-184 被引量:1
标识
DOI:10.54680/fr23310110612
摘要

BACKGROUND: Vitrification of embryos has become the basic means of assisted reproductive technology (ART) therapy in recent years. Concerns have also been raised about the safety of vitrification and the effect of cryopreservation time. Most of the previous studies were on the data within 6 years of cryopreservation. OBJECTIVE: In this study, we aimed to evaluate the impact of long-term cryopreservat ion (≥6 years) on pregnancy and neonatal outcomes. MATERIALS AND METHODS: This research was a single-center, retrospective analysis, including 426 frozen-thawed embryo transfer (FET) cycles. Patients who participated in IVF-FET cycles between January 2013 to December 2020 were analyzed. Preferentially matched participants were divided into three groups according to storage time: group A (≥72 months) , group B (0-3 months, propensity score matching [PSM] according to the age of oocyte retrieval), and group C (0-3 months, PSM according to the age of embryo transfer). RESULTS: Our results revealed that there were no significant differences in human chorionic gonadotropin [HCG] positive rate, clinical pregnancy rate, miscarriage rate, live birth rate, and neonatal outcomes when the embryo storage duration ≥72 months . But the proportion of high birth weight was higher in group A (≥72 months) when matched according to age at embryo transfer. CONCLUSION: The results of our study showed that long-term cryopreservation had no effect on the pregnancy and neonatal outcomes of vitrification. The results offer evidence for the safety of using long-term cryopreservation embryos after vitrification.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
丘比特应助YYDS54采纳,获得10
1秒前
科研通AI2S应助科研通管家采纳,获得10
1秒前
田様应助科研通管家采纳,获得10
2秒前
Charming应助科研通管家采纳,获得60
2秒前
赘婿应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
完美世界应助科研通管家采纳,获得10
2秒前
完美世界应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
杳鸢应助科研通管家采纳,获得20
2秒前
星辰大海应助科研通管家采纳,获得10
2秒前
maox1aoxin应助科研通管家采纳,获得30
2秒前
脑洞疼应助科研通管家采纳,获得10
2秒前
3秒前
Charming应助科研通管家采纳,获得20
3秒前
领导范儿应助科研通管家采纳,获得10
3秒前
充电宝应助科研通管家采纳,获得10
3秒前
杳鸢应助科研通管家采纳,获得20
3秒前
传奇3应助科研通管家采纳,获得10
3秒前
Charming应助科研通管家采纳,获得20
3秒前
英姑应助科研通管家采纳,获得10
3秒前
小遇完成签到 ,获得积分10
3秒前
3秒前
3秒前
zyc1111111发布了新的文献求助10
4秒前
记忆完成签到,获得积分10
6秒前
金金发布了新的文献求助10
8秒前
深情安青应助优雅八宝粥采纳,获得10
8秒前
传奇3应助完美的海秋采纳,获得150
9秒前
一枚研究僧举报求助违规成功
10秒前
Endlessway举报求助违规成功
10秒前
浅尝离白举报求助违规成功
10秒前
10秒前
Rian完成签到 ,获得积分10
11秒前
chen666发布了新的文献求助10
12秒前
热心晓丝发布了新的文献求助10
14秒前
一只五条悟完成签到,获得积分10
14秒前
15秒前
深情安青应助Man采纳,获得10
17秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
歯科矯正学 第7版(或第5版) 1004
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Security Awareness: Applying Practical Cybersecurity in Your World 6th Edition 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3241487
求助须知:如何正确求助?哪些是违规求助? 2885956
关于积分的说明 8241111
捐赠科研通 2554477
什么是DOI,文献DOI怎么找? 1382579
科研通“疑难数据库(出版商)”最低求助积分说明 649608
邀请新用户注册赠送积分活动 625279