The gut-lung axis: Mendelian randomization identifies a causal association between inflammatory bowel disease and interstitial lung disease

孟德尔随机化 医学 炎症性肠病 优势比 全基因组关联研究 内科学 间质性肺病 溃疡性结肠炎 胃肠病学 置信区间 疾病 单核苷酸多态性 基因型 遗传变异 遗传学 基因 生物
作者
Qinghua Luo,Ping Zhou,Shuangqing Chang,Zhifang Huang,Yuan Zhu
出处
期刊:Heart & Lung [Elsevier BV]
卷期号:61: 120-126 被引量:6
标识
DOI:10.1016/j.hrtlng.2023.05.016
摘要

Background Previous studies have suggested the association between interstitial lung disease (ILD) and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Objectives To examine the potential bidirectional causal relationship between IBD and ILD using the Mendelian randomization (MR) method. Methods We obtained the data from the genome-wide association studies (GWASs) in European individuals for IBD (25,042 cases and 34,915 controls) and ILD (21,806 cases and 196,986 controls) from the IEU GWAS database. We screened for instrumental variables based on the three assumptions of MR. The two-sample bidirectional MR analysis was performed using the inverse-variance weighted method and multiple sensitivity analyses. Results Genetic liability to IBD was significantly associated with an increased ILD risk (odds ratio (OR) = 1.20, 95% confidence interval (CI) = 1.17–1.24, p = 3.67E-33). When considering the IBD subtypes, ILD risk was associated with genetic liability to both CD (OR = 1.14, 95% CI = 1.10–1.17, p = 1.91E-17) and UC (OR = 1.16, 95% CI = 1.12–1.21, p = 3.51E-13). There was weak evidence for the effect of genetic liability to ILD on IBD (OR = 1.32, 95% CI = 0.99–1.76, p = 0.062), CD (OR = 1.25, 95% CI = 1.00–1.55, p = 0.046), and UC (OR = 1.47, 95%CI = 1.01–2.14, p = 0.046). Conclusion The results indicate a strong causal effect of IBD (including CD and UC) on ILD.
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