光热治疗
材料科学
石墨烯
等离子体子
纳米颗粒
等离子纳米粒子
胶体金
热导率
宽带
氧化物
光热效应
纳米技术
光电子学
光学
复合材料
物理
冶金
作者
Divya Khurana,Amit Kumar Shaw,Gourav Sharma,Manzoor Ahmed,Sanket Kumar Shukla,Sanjeev Soni
标识
DOI:10.1016/j.icheatmasstransfer.2024.107597
摘要
The choice of nanomaterial is crucial for achieving desired thermal ablation of a tumors, considering nanoparticle dose/concentration and near-infrared (NIR) irradiation parameters during plasmonic photothermal therapy (PPTT). Most studies prioritize use of nanoparticles with high photothermal conversion efficiency (η) for PPTT without emphasizing the thermal conductivity (κ) within a solid tumor. Herein, two broadband absorbing nanoparticles, i.e., gold nanoblackbodies (AuNBs) and graphene oxide (GO) nanoparticles, are compared for η under similar NIR irradiation and nanoparticles dose. Further, the effect of photothermal conversion and κ are studied through tumor-tissue mimicking phantoms mimicking invasive ductal carcinoma embedded with nanoparticles, surrounded by normal tissue region. Under similar conditions, η is higher in AuNBs (73.2%) than GO nanoparticles (63.7%), while κ of GO nanoparticles embedded phantom (0.62 W/mK) surpasses AuNBs embedded phantom (0.59 W/mK) by 5.08%. Photothermal response through tumor-tissue mimicking phantoms shows that GO nanoparticles achieve higher temperatures within the entire tumor region than AuNBs due to their high κ, despite having lower η. This finding suggests that η is not the sole parameter, and it is the coupled effect of η and κ for the choice/suitability of a nanoparticle to attain desired temperatures throughout the tumor for PPTT.
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