兴奋性突触后电位
谷氨酸的
神经科学
谷氨酸受体
胶质瘤
生物
受体
化学
细胞生物学
癌症研究
抑制性突触后电位
生物化学
作者
Eric A. Goethe,Benjamin Deneen,Jeffrey L. Noebels,Ganesh Rao
摘要
Glioblastoma is the most common malignant primary brain tumor. Recent studies have demonstrated that excitatory or activity-dependent signaling—both synaptic and non-synaptic—contribute to the progression of glioblastoma. Glutamatergic receptors may be stimulated via neuron–tumor synapses or release of glutamate by the tumor itself. Ion currents generated by these receptors directly alter the structure of membrane adhesion molecules and cytoskeletal proteins to promote migratory behavior. Additionally, the hyperexcitable milieu surrounding glioma increases the rate at which tumor cells proliferate and drive recurrent disease. Inhibition of excitatory signaling has shown to effectively reduce its pro-migratory and -proliferative effects.
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