Anticancer potential of curcumin-cyclodextrin complexes and their pharmacokinetic properties

Cancer is one of the most common diseases throughout the world, with many treatment modalities currently being used, and new treatment strategies being sought. Most chemotherapeutic molecules have shown extensive toxicity for normal cells, which leads to severe adverse effects. Chemotherapy may also lead to drug resistance, which is one of the major obstacles to the clinical treatment of cancer. Curcumin, a polyphenolic natural compound, has long been considered a therapeutic molecule for a variety of diseases and possesses anti-cancer, anti-oxidant, and anti-inflammatory properties. However, its use is limited due to its hydrophobic nature, poor solubility in water at acidic or neutral pH, and limited bioavailability at the tumor site. Cyclodextrin complexes of curcumin increase curcumin's water solubility, as well as its physicochemical stability to hydrolysis and photochemical decomposition. The most common type of cyclodextrin used for pharmaceutical preparations is β-cyclodextrin. This review focuses on different curcumin-cyclodextrin formulations and compares their pharmacokinetic parameters and efficacy.