Effects of Interventional Therapy on Liver Metastases-Measurement of Liver Volume by Abdominal Computed Tomography

Purpose: To evaluate the effects of transhepatic arterial infusion (TAI) with transcatheter arterial embolization (TAE) on liver volume of patients with liver metastases, by liver volumetry using 256-slice CT (iCT 256, Philips Healthcare). Methods: A retrospective analysis of 19 patients with liver metastases, who received combination treatment of TAI with TAE, were conducted. Residual liver volumes (LV) were measured before (LV 0 ), after the first (LV 1 ) and the second treatment (LV 2 ) with iCT 256. Bland-Altman method was used to evaluate the agreements of residual liver volume between two reviewers. Residual liver volume changes were compared by One-Way ANOVA. Results: For the first reviewer, LV 0 , LV 1 , LV 2 were: 872.67±139.31, 960.63±143.91, 842.13±141.45 cc. LV 1 > LV 0 , but the difference was not significant ( P = 0.061). LV 2 < LV 0 , the difference was statistically significant ( P = 0.013). LV 2 < LV 0 , and the difference was not statistically significant ( P = 0.509). For the second reviewer, LV 0 , LV 1 , LV 2 were: 909.99±135.46, 996.36±180.10, 845.70±131.632 cc. LV 1 > LV 0 , the difference was not statistically significant ( P = 0.083). LV 2 < LV 1 , the difference was statistically significant ( P = 0.003). LV 2 < LV 0 , the difference was not statistically significant ( P = 0.194). Conclusion: Combination treatment of TAI with TAE did not induce significant liver damage in patients with metastatic liver cancer, and iCT256 volumetry provided a precise measurement of liver volume and may play a critical role in the development of interventional surgery.