痴呆
医学
疾病
斯科普斯
观察研究
阿尔茨海默病
梅德林
重症监护医学
内科学
生物
生物化学
作者
Xian-Le Bu,Yan-Jiang Wang
标识
DOI:10.1016/s1473-3099(21)00258-9
摘要
Approximately 50 million people worldwide are estimated to currently have a type of dementia. 1 Frankish H Horton R Prevention and management of dementia: a priority for public health. Lancet. 2017; 390: 2614-2615 Summary Full Text Full Text PDF PubMed Scopus (75) Google Scholar Identification of risk factors is of importance for the prevention and treatment of dementia. Infections have been hypothesised to increase the risk for dementia; however, whether infections are potentially causative of dementia is unclear. 2 Itzhaki RF Golde TE Heneka MT Readhead B Do infections have a role in the pathogenesis of Alzheimer disease?. Nat Rev Neurol. 2020; 16: 193-197 Crossref PubMed Scopus (44) Google Scholar Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohortSevere infections requiring hospital treatment are associated with long-term increased risk of dementia, including vascular dementia and Alzheimer's disease. This association is not limited to CNS infections, suggesting that systemic effects are sufficient to affect the brain. The absence of infection specificity combined with evidence of dose-response relationships between infectious disease burden and dementia risk support the hypothesis that increased dementia risk is driven by general inflammation rather than specific microbes. Full-Text PDF Open Access
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