Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice

Journal of Food BiochemistryVolume 45, Issue 8 e13816 ORIGINAL ARTICLE Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice Yunfeng Bi, Yunfeng Bi College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Conceptualization, Writing - review & editingSearch for more papers by this authorQiuyang Li, Qiuyang Li orcid.org/0000-0002-9079-5147 College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Writing - original draft, Writing - review & editingSearch for more papers by this authorWeiming Tao, Weiming Tao College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Data curationSearch for more papers by this authorJinxin Tang, Jinxin Tang College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Formal analysisSearch for more papers by this authorGaofei You, Gaofei You College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: SoftwareSearch for more papers by this authorLei Yu, Corresponding Author Lei Yu leiyujl@sina.com College of Food science and Engineering, Jilin Agricultural University, Changchun, China Correspondence Yu Lei, College of Food science and Engineering, Jilin Agricultural University, Changchun 130118, China. Email: leiyujl@sina.com Contribution: Project administrationSearch for more papers by this author Yunfeng Bi, Yunfeng Bi College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Conceptualization, Writing - review & editingSearch for more papers by this authorQiuyang Li, Qiuyang Li orcid.org/0000-0002-9079-5147 College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Writing - original draft, Writing - review & editingSearch for more papers by this authorWeiming Tao, Weiming Tao College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Data curationSearch for more papers by this authorJinxin Tang, Jinxin Tang College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: Formal analysisSearch for more papers by this authorGaofei You, Gaofei You College of Food science and Engineering, Jilin Agricultural University, Changchun, China Contribution: SoftwareSearch for more papers by this authorLei Yu, Corresponding Author Lei Yu leiyujl@sina.com College of Food science and Engineering, Jilin Agricultural University, Changchun, China Correspondence Yu Lei, College of Food science and Engineering, Jilin Agricultural University, Changchun 130118, China. Email: leiyujl@sina.com Contribution: Project administrationSearch for more papers by this author First published: 21 June 2021 https://doi.org/10.1111/jfbc.13816Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract With the development of technology, drugs are being developed for different purposes. Thus, the rate of drug injury considerably increased worldwide. Liver is the largest detoxification organ in the human body, but it is also the organ most vulnerable to drug damage. Ginsenoside Rg1 has been reported to have an extensive protective effect on liver injury. However, no evident results showed whether ginsenoside Rh1 could improve the injury caused by drugs. Therefore, this paper aimed to explore the protective effect in a mouse model with liver injury. Mice administered with acetaminophen (APAP) were used as the negative group, while those administered with Rg1 (10, 20, and 30 mg/kg) and Rh1 (10, 20, and 30 mg/kg) were used as the prevention groups. Results indicated that the treatments increased the levels of GSH and SOD remarkably and decreased that of MDA. In addition, the expression levels of GOT and GPT was remarkably reduced compared with the negative group. Inflammatory agents TNF-α, IL-6, and IL-1β were also decreased by the treatments. Meanwhile, Rg1 and Rh1 not only prevented the expression of Bax but also promoted Bcl-2 levels in mice. All results suggested that ginsenoside Rg1 and ginsenoside Rh1 exerted a preventive effect on APAP-induced liver injury in mice. Practical applications With the increasing number of patients suffering from drug-induced liver injury, it is urgent to find alternative natural plant drugs to treat liver injury. This paper focuses on the protective effects of Ginsenoside Rg1 and ginsenoside Rh1 on acetaminophen (APAP) induced liver injury. From the previous studies, we found that there is no sufficient evidence to show that ginsenoside Rh1 has protective effect on liver injury. In this paper, the detection of oxidative stress indicators, liver histopathological analysis and immunoprotein analysis show that both ginsenoside Rg1 and ginsenoside Rh1 have preventive effect on liver injury caused by APAP, which provides a reference for the follow-up experimental research. Open Research DATA AVAILABILITY STATEMENT Supplementary material related to this article can be obtained from the corresponding author on request. Citing Literature Volume45, Issue8August 2021e13816 RelatedInformation