光热治疗
磁共振成像
材料科学
介孔二氧化硅
热疗
化疗
放射治疗
生物相容性材料
化学
纳米技术
生物医学工程
介孔材料
医学
放射科
外科
催化作用
生物化学
内科学
作者
Hang Zhao,Jiaqi Wang,Xi Li,Yinwen Li,Chunlin Li,Xiang Wang,Jinxia Wang,Shaoqi Guan,Yupeng Xu,Guoying Deng,Ying Chen,Jie Lü,Xijian Liu
标识
DOI:10.1016/j.jcis.2021.06.174
摘要
Cancer is a leading cause of death worldwide and seriously threatens the health of humans. The current clinical treatments for cancer are not efficient and always lead to significant side effects. Herein, a biocompatible and powerful theranostic agent ([email protected]2@MnO2/DOX) is fabricated using a facile stepwise reaction method. The Bi nanoparticles (NPs) are coated by mesoporous silica to protect the Bi NPs from oxidation, which guarantees the stable photothermal effect of the Bi NPs. When the [email protected]2@MnO2/DOX nanocomposites (NCs) accumulate in the tumour site, hyperthermia is generated by Bi NPs under near-infrared (NIR) light irradiation for photothermal therapy (PTT), and the generated heat triggers the release of DOX for chemotherapy in the tumour. In addition, the MnO2 of the NCs responsively catalyses endogenous H2O2 to generate O2, raising the oxygen level to enhance the effect of chemotherapy in the tumour microenvironment (TME), and consumes glutathione (GSH) to produce Mn2+ for magnetic resonance (MR) imaging. Under acidic TME conditions, H2O2 and Mn2+ also produce toxic hydroxyl radical (·OH) for chemodynamic therapy (CDT). Furthermore, the Bi NPs can also be used as excellent contrast agents for X-ray computed tomography (CT) imaging of tumours with a high CT value (6.865 HU mM−1). The [email protected]2@MnO2/DOX NCs exhibit a powerful theranostic performance for CT/MR imaging-guided enhanced PTT/CDT/chemotherapy, which opens a new prospect to rationally design theranostic agents for tumour imaging.
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