Racial/ethnic disparities in risk of breast cancer mortality by molecular subtype and stage at diagnosis

乳腺癌 医学 肿瘤科 危险系数 癌症 流行病学 太平洋岛民 内科学 民族 比例危险模型 阶段(地层学) 妇科 人口学 人口 生物 环境卫生 人类学 社会学 古生物学 置信区间
作者
Nicole C. Loroña,Kathleen E. Malone,Christopher I. Li
出处
期刊:Breast Cancer Research and Treatment [Springer Science+Business Media]
卷期号:190 (3): 549-558 被引量:8
标识
DOI:10.1007/s10549-021-06311-7
摘要

Previous research has found significant survival disparities between Black and White women among select stages and subtypes of breast cancer, however other racial/ethnic groups have been less well-studied. This study expands on previous research, examining differences in breast cancer-specific mortality across multiple racial and ethnic groups.Women diagnosed with a first primary invasive breast cancer between 2010 and 2016 who were 20-85 years of age at diagnosis were identified from 18 Surveillance, Epidemiology, and End Results (SEER) registries. Subtypes were defined by joint hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. Cox proportional hazards models for each stage and subtype were fit, with non-Hispanic white women as the reference group. Effect modification by age at diagnosis (< 50, ≥ 50) was found and thus analyses were age-stratified.After multivariable adjustment, younger Black women had greater risks of breast cancer-specific death for all stages of HR+/HER2-, and certain stages of HR+/HER2+ , TN, and HR-/HER2 + breast cancer. Asian/Pacific Islander women generally had a lower hazard of breast cancer-specific death. Older Hispanic White women had a lower hazard of breast cancer-specific death for stages I-III HR + /HER2- and stage II TN breast cancer.These findings demonstrate that different racial/ethnic groups experience different risks of breast cancer-specific mortality by stage and subtype. Efforts to address survival disparities should place additional focus on young Black women, as they experience meaningful disparities in breast cancer-specific mortality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
无花果应助Zymiao采纳,获得10
1秒前
2秒前
小王爱学习给小王爱学习的求助进行了留言
3秒前
Liu关闭了Liu文献求助
4秒前
5秒前
Ni发布了新的文献求助10
5秒前
5秒前
kimiweiwei完成签到,获得积分10
7秒前
1234发布了新的文献求助10
7秒前
wangying完成签到,获得积分10
8秒前
狗子完成签到 ,获得积分10
9秒前
身强力壮运气好完成签到,获得积分10
9秒前
Miki发布了新的文献求助10
9秒前
Cici发布了新的文献求助10
10秒前
抽屉里的砖头完成签到,获得积分10
10秒前
黑虎发布了新的文献求助10
11秒前
13秒前
Broccoli发布了新的文献求助10
13秒前
李健的粉丝团团长应助CFF采纳,获得10
14秒前
脑洞疼应助超帅的又槐采纳,获得10
14秒前
15秒前
完美的大米完成签到,获得积分10
16秒前
果冻橙发布了新的文献求助10
17秒前
iui飞发布了新的文献求助10
18秒前
大头粽完成签到,获得积分10
18秒前
量子星尘发布了新的文献求助10
18秒前
monica-q完成签到,获得积分10
18秒前
花花猪1989发布了新的文献求助20
19秒前
灿烂完成签到,获得积分10
21秒前
21秒前
21秒前
22秒前
22秒前
水门发布了新的文献求助30
24秒前
lulu加油发布了新的文献求助30
25秒前
26秒前
27秒前
图治完成签到,获得积分10
27秒前
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969940
求助须知:如何正确求助?哪些是违规求助? 3514642
关于积分的说明 11175298
捐赠科研通 3249947
什么是DOI,文献DOI怎么找? 1795178
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891