Racial/ethnic disparities in risk of breast cancer mortality by molecular subtype and stage at diagnosis

乳腺癌 医学 肿瘤科 危险系数 癌症 流行病学 太平洋岛民 内科学 民族 比例危险模型 阶段(地层学) 妇科 人口学 人口 生物 环境卫生 人类学 社会学 古生物学 置信区间
作者
Nicole C. Loroña,Kathleen E. Malone,Christopher I. Li
出处
期刊:Breast Cancer Research and Treatment [Springer Science+Business Media]
卷期号:190 (3): 549-558 被引量:8
标识
DOI:10.1007/s10549-021-06311-7
摘要

Previous research has found significant survival disparities between Black and White women among select stages and subtypes of breast cancer, however other racial/ethnic groups have been less well-studied. This study expands on previous research, examining differences in breast cancer-specific mortality across multiple racial and ethnic groups.Women diagnosed with a first primary invasive breast cancer between 2010 and 2016 who were 20-85 years of age at diagnosis were identified from 18 Surveillance, Epidemiology, and End Results (SEER) registries. Subtypes were defined by joint hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. Cox proportional hazards models for each stage and subtype were fit, with non-Hispanic white women as the reference group. Effect modification by age at diagnosis (< 50, ≥ 50) was found and thus analyses were age-stratified.After multivariable adjustment, younger Black women had greater risks of breast cancer-specific death for all stages of HR+/HER2-, and certain stages of HR+/HER2+ , TN, and HR-/HER2 + breast cancer. Asian/Pacific Islander women generally had a lower hazard of breast cancer-specific death. Older Hispanic White women had a lower hazard of breast cancer-specific death for stages I-III HR + /HER2- and stage II TN breast cancer.These findings demonstrate that different racial/ethnic groups experience different risks of breast cancer-specific mortality by stage and subtype. Efforts to address survival disparities should place additional focus on young Black women, as they experience meaningful disparities in breast cancer-specific mortality.
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