医学
褪黑素
肝硬化
脂肪肝
疾病
肝病
睡眠(系统调用)
慢性肝病
生物信息学
内科学
酒精性肝病
脑病
睡眠障碍
精神科
认知
生物
计算机科学
操作系统
作者
Thomas Marjot,David Ray,Felicity Williams,Jeremy Tomlinson,Matthew J. Armstrong
标识
DOI:10.1016/s2468-1253(21)00169-2
摘要
Summary
Sleep is a complex, highly regulated process essential for human health and wellbeing. Increasingly, sleep–wake disturbance has been implicated in the pathogenesis of chronic liver disease, particularly the development and progression of non-alcoholic fatty liver disease and alcohol-related liver disease. Patients with cirrhosis also have a high burden of sleep abnormalities with substantial implications for their quality of life and physical health. This Review summarises the epidemiology and pathophysiology of sleep–wake disturbance in liver disease and discusses the multiple converging pathways leading to abnormal sleeping patterns in patients with cirrhosis. This includes contributions from altered melatonin metabolism, neuromuscular complications, and aberrant thermoregulation. In turn, a vicious cycle is established whereby disrupted sleep can further contribute to liver disease progression. We also begin to unravel the complex, interlinking relationship between sleep–wake disturbance and hepatic encephalopathy, discussing both overlapping and distinct mechanisms and clinical features. Finally, we summarise the current and future therapeutic approaches aiming to improve sleep quality in patients with cirrhosis.
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