Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study

医学 内科学 胃肠病学 胆囊疾病 胆囊癌 疾病 胰腺癌 胆囊 病例对照研究 癌症 普通外科
作者
Valentina Rosato,Paulina Gomez‐Rubio,Esther Molina‐Montes,Mirari Márquez,Matthias Löhr,Michael O’Rorke,Christoph Michalski,Xavier Molero,Antoni Farré,José Perea,Jörg Kleeff,Tatjana Crnogorac‐Jurcevic,William Greenhalf,Lucas Ilzarbe,Adonina Tardón,Thomas M. Gress,Víctor Manuel Barberá,J. Enrique Domínguez‐Muñoz,Luís Muñoz‐Bellvis,J. Balsells,Eithne Costello,Mar Iglesias,Bo Kong,Josefina Móra,Damian O’Driscoll,Ignasi Poves,Aldo Scarpa,W Ye,Manuel Hidalgo,Linda Sharp,Alfredo Carrato,Francisco X. Real,Carlo La Vecchia,Núria Malats
出处
期刊:European Journal of Cancer Prevention [Lippincott Williams & Wilkins]
卷期号:30 (6): 423-430 被引量:1
标识
DOI:10.1097/cej.0000000000000588
摘要

Background and aims: The overall evidence on the association between gallbladder conditions (GBC: gallstones and cholecystectomy) and pancreatic cancer (PC) is inconsistent. To our knowledge, no previous investigations considered the role of tumour characteristics on this association. Thus, we aimed to assess the association between self-reported GBC and PC risk, by focussing on timing to PC diagnosis and tumour features (stage, location, and resection). Methods: Data derived from a European case-control study conducted between 2009 and 2014 including 1431 PC cases and 1090 controls. We used unconditional logistic regression models to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) adjusted for recognized confounders. Results: Overall, 298 (20.8%) cases and 127 (11.6%) controls reported to have had GBC, corresponding to an OR of 1.70 (95% CI 1.33–2.16). The ORs were 4.84 (95% CI 2.96–7.89) for GBC diagnosed <3 years before PC and 1.06 (95% CI 0.79–1.41) for ≥3 years. The risk was slightly higher for stage I/II (OR = 1.71, 95% CI 1.15–2.55) vs. stage III/IV tumours (OR = 1.23, 95% CI 0.87–1.76); for tumours sited in the head of the pancreas (OR = 1.59, 95% CI 1.13–2.24) vs. tumours located at the body/tail (OR = 1.02, 95% CI 0.62–1.68); and for tumours surgically resected (OR = 1.69, 95% CI 1.14–2.51) vs. non-resected tumours (OR = 1.25, 95% CI 0.88–1.78). The corresponding ORs for GBC diagnosed ≥3 years prior PC were close to unity. Conclusion: Our study supports the association between GBC and PC. Given the time-risk pattern observed, however, this relationship may be non-causal and, partly or largely, due to diagnostic attention and/or reverse causation.
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