拉西地平
剂型
色谱法
生物分析
检出限
药物制剂
生物制药
化学
生物流体
敌手
生物化学
受体
生物
遗传学
作者
Tejasvini Sai Chebrolu,Lalit Kumar,Ruchi Verma
出处
期刊:Bioanalysis
[Future Science Ltd]
日期:2021-06-01
卷期号:13 (12): 1011-1024
被引量:3
标识
DOI:10.4155/bio-2021-0024
摘要
Lacidipine (LAC) is a calcium antagonist used in the treatment of hypertension. It is a lipophilic drug containing dihydropyridine ring that is responsible for the activity. This review article gives an overview of various analytical techniques proposed for the determination of LAC in pharmaceutical dosage forms, in pure form, in biological fluids and to determine characteristics of LAC in modified release dosage forms. Ultra violet/visible spectrophotometric, spectroflourimetric, high performance liquid chromatography, high performance thin layer chromatography, electro-analytical, bioanalytical and miscellaneous methods such as microbiological assay, X-ray diffraction, differential scanning calorimetry, were discussed. Various parameters such as system suitability, selectivity, linearity, precision, accuracy, limit of detection, limit of quantification and robustness have been discussed for the employed methods.
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