肉桂醛
光动力疗法
单线态氧
化学
活性氧
光敏剂
合理设计
氧化应激
细胞毒性
癌细胞
体外
内生
光化学
生物物理学
癌症研究
生物化学
氧气
纳米技术
癌症
有机化学
催化作用
内科学
材料科学
生物
医学
作者
Qifan Xu,Ruijing Zhang,Hang Zhang,Guoqing Jin,Bing‐Wu Wang,Mengliang Zhu,Jing Zhang,Song Gao,Junlong Zhang
标识
DOI:10.1142/s1088424621501054
摘要
Photodynamic therapy (PDT) is a non-invasive method for cancer treatment that relies on the generation of excess reactive oxygen species (ROS), upon excitation of photosensitizer (PS), to eradicate tumor cells. However, the overexpress of endogenous antioxidants in tumor cells will eliminate the ROS and restrict the therapeutic efficacy of PDT. Herein, a novel type of PS was developed by conjugating cinnamaldehyde (CA), a kind of oxidative stress amplified agent, with porpholactam through a hydrazone bond. The new PS retains the photophysical properties of porpholactam, which displays high singlet oxygen quantum yield for the PDT function. The results of in vitro experiments performed including ROS assay and the cytotoxicity in cancer cells suggest that the rational design of the novel porpholactam-CA derivatives result in enhanced ROS generation upon irradiation, providing a possible approach to achieve enhanced therapeutic effects in PDT.
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