线粒体
细胞凋亡
生物
程序性细胞死亡
有机体
细胞生物学
人口
细胞器
细胞应激反应
机制(生物学)
神经科学
战斗或逃跑反应
遗传学
医学
基因
环境卫生
认识论
哲学
标识
DOI:10.1016/s0098-2997(99)00008-4
摘要
The review summarizes the present state of our knowledge concerning alternative functions of mitochondria, namely energy conservation in forms of protonic potential and ATP, thermoregulatory energy dissipation as heat, production of useful substances, decomposition of harmful substances, control of cellular processes. The recent progress in understanding of some mitochondrion-linked pathologies is described. The role of reactive oxygen species in these processes is stressed. Possible mechanisms of programmed death of mitochondrion (mitoptosis), cell (apoptosis) and organism (phenoptosis) are considered. A concept is put forward assuming that mitoptosis is involved in some types of apoptosis whereas apoptosis can be a part of a phenoptotic cascade. It is hypothesized that septic shock, as well as the stress-induced brain and heart ischemic diseases and cancer, exemplify mechanisms of phenoptosis purifying population, community of organisms or kin from dangerous or useless individuals.
科研通智能强力驱动
Strongly Powered by AbleSci AI