Highly Diastereo‐ and Enantioselective Formal Conjugate Addition of Nitroalkanes to Nitroalkenes by Chiral Ammonium Bifluoride Catalysis

A matter of control: A chiral quaternary ammonium bifluoride catalyst in combination with silyl nitronates results in the highly diastereo- and enantioselective formal conjugate addition of nitroalkanes to nitroalkenes (see scheme). The resulting 1,3-dinitro compounds bear two defined stereocenters, which can serve as versatile chiral building blocks in organic synthesis.