Diphenylmethyl and tetrahydropyranyl protecting groups in the synthesis of 3-substituted 5-amino- and 5-hydrazino-1,2,4-triazoles

The use of hydrazine as reagent in nucleophilic substitution and reduction in the 1,2,4-triazole series in combination with introduction of labile protecting groups makes it possible to synthesize 5-hydrazino-3-nitro-1H-1,2,4-triazole and 3-chloro-5-hydrazino-1H-1,2,4-triazol-5-ylhydrazine which were difficultly accessible previously, as well as to extend the series of 3-substituted 5-amino-1H-1,2,4-triazoles.