Techniques to Detect Defining Chromosomal Translocations/Abnormalities

There are multiple techniques to detect defining chromosomal translocations and other abnormalities, including conventional cytogenetic analysis, fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), DNA microarray analysis, polymerase chain reaction (PCR) analysis, and immunohistochemical (IHC) analysis. These various techniques with their advantages and limitations will be discussed in this chapter.