生物
核孔
核运输
细胞生物学
整合酶
核心
人类免疫缺陷病毒(HIV)
限制
细胞核
病毒包膜
病毒学
计算生物学
机械工程
工程类
作者
Michael P. Sherman,Warner C. Greene
标识
DOI:10.1016/s1286-4579(01)01511-8
摘要
HIV infection of non-dividing cellular targets like macrophages requires successful passage of the viral preintegration complex (PIC) across an intact nuclear envelope. Unique but redundant nuclear import signals reside within the HIV integrase, matrix, and Vpr proteins as well as the 'DNA flap'; these signals appear to facilitate PIC transport through the limiting nuclear pores. We discuss recent studies that have advanced our understanding of this key step in the HIV life cycle.
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