Abnormal Intestinal Histology in Neonates with Congenital Anomalies of the Gastrointestinal Tract

组织学 地穴 胃肠道 固有层 医学 胎儿 子宫内 小肠 病理 解剖 肠细胞 回肠 妊娠期 生物 胃肠病学 内科学 生理学 怀孕 上皮 遗传学
作者
Adria A. Condino,Aaron A. Barleycorn,Wenzhe Lu,Akhil Maheshwari,Robert D. Christensen,Darlene A Calhoun
出处
期刊:Neonatology [Karger Publishers]
卷期号:85 (3): 145-150 被引量:29
标识
DOI:10.1159/000075064
摘要

In animal models, when swallowing is experimentally prevented in utero, bowel length and weight are reduced, and villus height, crypt depth, and villus function are retarded. Little is known about the intestinal histology in infants with gastrointestinal (GI) tract anomalies. We examined the histological architecture of the intestine in neonates with GI anomalies in comparison to that of normal fetuses. Villus height, area, and length and crypt depth of normal fetuses were quantified in the proximal small bowel (n = 11) and measurements compared to those of surgical specimens of neonates with congenital anomalies of the GI tract (n = 16). Villus height and area and lamina propria height and area increased linearly from 8 to 24 weeks of gestation. In infants with anomalies of the GI tract, the villi were blunted and lacked normal histological architecture, the crypts were disorganized, and the crypt depth was significantly decreased (p = 0.004). Enterocyte height and area were significantly greater in neonates with congenital anomalies of the GI tract. The intestinal histology in neonates with congenital anomalies of the GI tract differs significantly from that of normal fetuses.
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