体内
化学
计算生物学
甲苯
蛋白质工程
生物化学
蛋白质化学
生物物理学
配体(生物化学)
细胞生物学
生物
受体
立体化学
酶
遗传学
作者
Shinya Tsukiji,Masayoshi Miyagawa,Yousuke Takaoka,Tomonori Tamura,Itaru Hamachi
摘要
Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living cells, tissues and mice but also for constructing a biosensor directly inside cells without genetic engineering. These data establish LDT chemistry as a new tool for the study and manipulation of biological systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI