α-Amidation of Cyclic Ethers Catalyzed by Simple Copper Salt and a Mild and Efficient Preparation Method for α,ϖ-Amino Alcohols

Copper(II) trifluoromethanesulfonate catalyzed the amidation of cyclic ethers with iminoiodanes under mild conditions (CH2Cl2, 40 °C) with good yields (up to 86% based on 97% conversion) and selectivity (only α-amino products were found). Subsequently, the tosylamidated products could undergo a reductive ring-opening reaction to give α,ϖ-amino alcohols.