医学
安慰剂
血糖性
腰围
丙二醛
超重
内科学
橙色(颜色)
氧化应激
腹部肥胖
内分泌学
肥胖
糖尿病
食品科学
化学
替代医学
病理
作者
Constantin Dallas,Alain Gerbi,Yves Elbez,Philippe Caillard,Nicolas Zamaria,M Cloarec
摘要
The present study investigated the efficacy and safety effects of Sinetrol‐XPur (polyphenolic citrus dry extract) in weight management; metabolic parameters; and inflammatory, glycemic and oxidative status. In a 12‐week, randomized, double‐blind, placebo‐controlled trial, Sinetrol‐XPur was given to overweight subjects twice daily with meals in the tested group ( N = 47) versus a placebo group ( N = 48). Waist and hip circumference and abdominal fat were decreased in the Sinetrol‐XPur group as compared with the placebo group ( p < 0.0001) (−5.71% vs −1.56% for waist, −4.71% vs −1.35% for hip and −9.73% vs −3.18% for fat). Inflammatory markers were reduced (C‐reactive protein: −22.87% vs +61%; fibrinogen: −19.93% vs −1.61%, p < 0.01). Oxidative stress was lowered as seen by the reduction of malondialdehyde (−14.03% vs 2.76%) and the increase in superoxide dismutase and glutathione (17.38% vs 2.19% and 4.63% vs −2.36%, respectively, p < 0.01). No adverse effects were observed. Kidney, liver, and lipid panels remained unchanged. These results indicated that Sinetrol‐XPur supplementation is a viable option for reducing abdominal fat, waist and hip circumference, and body weight and for improving inflammatory, glycemic, and oxidative status in healthy overweight individuals. Copyright © 2013 John Wiley & Sons, Ltd.
科研通智能强力驱动
Strongly Powered by AbleSci AI