Protective effects of phosphatidylcholine on oxaliplatin-induced neuropathy in rats

奥沙利铂 氧化应激 周围神经病变 谷胱甘肽过氧化物酶 超氧化物歧化酶 医学 谷胱甘肽 抗氧化剂 药理学 坐骨神经 内分泌学 丙二醛 麻醉 内科学 化学 生物化学 结直肠癌 癌症 糖尿病
作者
Sung Tae Kim,Yoon Hee Chung,Ho Sung Lee,Su Jin Chung,Jong Hyuk Lee,Uy Dong Sohn,Yong Kyoo Shin,Eon Sub Park,Hyoung‐Chun Kim,Joon Seok Bang,Ji Hoon Jeong
出处
期刊:Life Sciences [Elsevier BV]
卷期号:130: 81-87 被引量:37
标识
DOI:10.1016/j.lfs.2015.03.013
摘要

The present study was designed to investigate the therapeutic potential of phosphatidylcholine (PC) on oxaliplatin-induced peripheral neuropathy. Male Sprague–Dawley rats were randomly divided into three groups: the control group, the oxaliplatin group (4 mg/kg, twice per week for 4 weeks) and the oxaliplatin + PC (300 mg/kg) group. To evaluate the effect of PC, we examined the thermal nociceptive threshold changes in oxaliplatin-induced peripheral neuropathy by conducting paw pressure, hot-plate and tail-flick tests. Additional experiments on the degree of oxidative stress in the sciatic nerves were performed by measuring the level of MDA, total glutathione (GSH), glutathione peroxidase (GPx) activity and superoxide dismutase (SOD) activity. We also used histopathological and immunohistochemical methods to observe neuronal damage and glial activation. PC attenuated oxidative stress by increasing antioxidant levels. In histopathological evaluation, the PC administrated group maintained normal morphologic appearance of sciatic nerves, similar to the control group. In spinal cords, however, no significant difference between the oxaliplatin-alone group and the oxaliplatin + PC group was observed. In the immunohistochemical evaluation, PC administration ameliorated oxaliplatin-induced microglial activation. It is suggested that PC has a therapeutic potential against oxaliplatin-induced peripheral neuropathy due to its antioxidant property and modulation of microglial activities.
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