细胞外基质
细胞生物学
背景(考古学)
再生(生物学)
功能(生物学)
平衡
信号转导
受体
细胞功能
碎片(计算)
细胞信号
生物
再生医学
化学
细胞
计算生物学
生物化学
干细胞
生态学
古生物学
作者
Stavros Garantziotis,Rashmin C. Savani
标识
DOI:10.1016/j.matbio.2019.02.002
摘要
Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.
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