Multicenter Metal–Organic Framework‐Based Ratiometric Fluorescent Sensors

Abstract Metal–organic frameworks (MOFs) with multiple emission centers are newly emerging as ratiometric sensors owing to their high sensitivity and high selectivity toward a wide range of targeted functional species. Energy transfer between the light‐absorbing group and emission centers and between different emission centers is the key to rationally design and synthesize MOF‐based ratiometric sensors. A good match between the energy levels of the light‐absorbing groups and emission centers is the prerequisite for MOF‐based sensors to exhibit multiple emissions, and a good match of the MOF‐based sensors and those of the targeted species can increase the sensitivity and selectivity, but this match is highly challenging to obtain via synthesis. MOFs with multiple emission centers can be produced by functionalizing MOFs with multiple lanthanide centers, organic luminophores, dyes, carbon dots, and other such emissive groups. In this progress report, recent advances in the strategies for synthesizing MOFs with multiple emission centers and their applications for ratiometric sensing of solution conditions, including the pH value, and ion, organic molecule, and biomolecule concentrations, are summarized, as are the related sensing mechanisms.