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Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies

预测(人工智能) 心理学 荟萃分析 萧条(经济学) 脑电图 功能磁共振成像 大脑活动与冥想 认知心理学 神经科学 听力学 医学 计算机科学 内科学 宏观经济学 人工智能 经济
作者
Hanna Keren,Georgia O’Callaghan,Pablo Vidal‐Ribas,George A. Buzzell,Melissa A. Brotman,Ellen Leibenluft,Pedro Mário Pan,Liana Meffert,Ariela Kaiser,Selina Wolke,Daniel S. Pine,Argyris Stringaris
出处
期刊:American Journal of Psychiatry [American Psychiatric Association]
卷期号:175 (11): 1111-1120 被引量:395
标识
DOI:10.1176/appi.ajp.2018.17101124
摘要

Objective: A role for aberrant reward processing in the pathogenesis of depression has long been proposed. However, no review has yet examined its role in depression by integrating conceptual and quantitative findings across functional MRI (fMRI) and EEG methodologies. The authors quantified these effects, with an emphasis on development. Method: A total of 38 fMRI and 12 EEG studies were entered into fMRI and EEG meta-analyses. fMRI studies primarily examined reward anticipation and reward feedback. These were analyzed using the activation likelihood estimation method. EEG studies involved mainly the feedback-related negativity (FRN) event-related potential, and these studies were analyzed using random-effects meta-analysis of the association between FRN and depression. Results: Analysis of fMRI studies revealed significantly reduced striatal activation in depressed compared with healthy individuals during reward feedback. When region-of-interest analyses were included, reduced activation was also observed in reward anticipation, an effect that was stronger in individuals under age 18. FRN was also significantly reduced in depression, with pronounced effects in individuals under age 18. In longitudinal studies, reduced striatal activation in fMRI and blunted FRN in EEG were found to precede the onset of depression in adolescents. Conclusions: Taken together, the findings show consistent neural aberrations during reward processing in depression, namely, reduced striatal signal during feedback and blunted FRN. These aberrations may underlie the pathogenesis of depression and have important implications for development of new treatments.
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