A Tripeptide/Hexapeptide Anti-Aging Regimen that Targets Both Collagen and Elastin, and Improves both Physician and Subject Scoring of Facial Aesthetics

Background: A tripeptide/hexapeptide (TriHex) anti-aging regimen with a select blend of peptides and botanicals targeting skin aging by multiple actions was developed.The TriHex regimen was formulated to help clear the extracellular matrix (ECM) of degraded proteins and promote collagen and elastin production.Aim: To assess the efficacy of an anti-aging regimen on moderate facial wrinkles and skin sagging.Methods: Five subjects followed the anti-aging regimen for 12 weeks.Clinical photography, subject satisfaction surveys, subject global assessment, and physician grading were used to evaluate results.Results: After subjects followed the anti-aging regimen for 12 weeks, statistically significant gains were noted in all physician-graded parameters.Compared to baseline, average percent improvements in skin fine lines (by 27.7%), radiance (by 44.8%), firmness (by 37.2%), plumpness (by 31.6%),sagginess, and wrinkles (both by 29.0%) were observed.Similarly, the subject global assessment showed changes in most photoaging parameters, with positive effects noted as early as 8 weeks of use by a majority of subjects.By 12 weeks of use, all subjects either strongly agreed or agreed that the TriHex formulation improved their skin quality in each category measured by the survey.Conclusions: Both subject and physician evaluations showed significant improvement in facial photoaging as early as 8 weeks after use of this tripeptide/hexapeptide anti-aging regimen.The anti-aging regimen improves multiple signs of photoaging using a synergistic blend of peptides and active botanicals.