舞蹈病
亨廷顿病
疾病
医学
人口
萧条(经济学)
精神科
退行性疾病
遗传学
内科学
生物
环境卫生
宏观经济学
经济
作者
Kenneth H. Fischbeck,Nancy S. Wexler
摘要
Huntington's disease is a severe autosomal-dominant neurodegenerative disorder that involves chorea, cognitive decline, and psychological problems such as depression, delusions, and impulsive behavior. Nowhere are the manifestations more striking than around Lake Maracaibo in northwestern Venezuela, where the disease is almost epidemic. The Huntington's disease kindreds in Venezuela encompass more than 18,000 persons spanning 10 generations. DNA samples from nearly 4000 patients and family members in this area were used to map the Huntington's gene to chromosome 4 in 19831 and to identify the disease gene in 1993.2 Subsequent studies in this population have discovered modifiers of age at onset.3 . . .
科研通智能强力驱动
Strongly Powered by AbleSci AI