计算机科学
相互作用体
管道(软件)
注释
推论
杠杆(统计)
数据科学
数据挖掘
资源(消歧)
计算生物学
人工智能
生物
基因
计算机网络
生物化学
程序设计语言
作者
Yingyao Zhou,Bin Zhou,Lars Pache,Max W. Chang,Alireza Hadj Khodabakhshi,Olga Tanaseichuk,Chris Benner,Sumit K. Chanda
标识
DOI:10.1038/s41467-019-09234-6
摘要
A critical component in the interpretation of systems-level studies is the inference of enriched biological pathways and protein complexes contained within OMICs datasets. Successful analysis requires the integration of a broad set of current biological databases and the application of a robust analytical pipeline to produce readily interpretable results. Metascape is a web-based portal designed to provide a comprehensive gene list annotation and analysis resource for experimental biologists. In terms of design features, Metascape combines functional enrichment, interactome analysis, gene annotation, and membership search to leverage over 40 independent knowledgebases within one integrated portal. Additionally, it facilitates comparative analyses of datasets across multiple independent and orthogonal experiments. Metascape provides a significantly simplified user experience through a one-click Express Analysis interface to generate interpretable outputs. Taken together, Metascape is an effective and efficient tool for experimental biologists to comprehensively analyze and interpret OMICs-based studies in the big data era. With the increasing obtainability of multi-OMICs data comes the need for easy to use data analysis tools. Here, the authors introduce Metascape, a biologist-oriented portal that provides a gene list annotation, enrichment and interactome resource and enables integrated analysis of multi-OMICs datasets.
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