医学
四分位间距
改良兰金量表
优势比
溶栓
中性粒细胞与淋巴细胞比率
内科学
冲程(发动机)
闭塞
脑出血
心脏病学
蛛网膜下腔出血
淋巴细胞
缺血
心肌梗塞
缺血性中风
工程类
机械工程
作者
Nitin Goyal,Georgios Tsivgoulis,Jason J. Chang,Konark Malhotra,Abhi Pandhi,Muhammad Ishfaq,Diana Alsbrook,Adam S Arthur,Lucas Elijovich,Andrei V. Alexandrov
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2018-07-12
卷期号:49 (8): 1985-1987
被引量:113
标识
DOI:10.1161/strokeaha.118.021477
摘要
Background and Purpose- The purpose of this study is to evaluate the relationship between neutrophil-to-lymphocyte ratio (NLR) at admission with safety and efficacy outcomes in acute stroke patients with large vessel occlusion after mechanical thrombectomy. Methods- Consecutive large vessel occlusion patients treated with mechanical thrombectomy during a 4-year period were evaluated. Outcome measures included symptomatic intracranial hemorrhage, 3-month mortality, successful reperfusion (modified Thrombolysis in Cerebral Infarction score of 2b/3), and 3-month functional independence (modified Rankin Scale scores of 0-2). Results- A total of 293 large vessel occlusion patients underwent mechanical thrombectomy (median admission NLR, 3.5; interquartile range [IQR], 1.7-6.8). In initial univariable analyses, higher median admission NLR values were documented in patients with symptomatic intracranial hemorrhage (8.5; IQR, 4.7-11.3) versus (3.9; IQR, 1.9-6.5); P<0.001 and individuals who were dead at 3-months (5.4; IQR, 2.8-9.6) versus (4.0; IQR, 1.8-6.4); P=0.004. Lower NLR values were recorded in patients with 3-month functional independence (3.7; IQR, 1.7-6.5) versus (4.3; IQR, 2.6-8.3); P=0.039. After adjustment for potential confounders, a 1-point increase in NLR was independently associated with higher odds of symptomatic intracranial hemorrhage (odds ratio, 1.11; 95% CI, 1.03-1.20; P=0.006) and 3-month mortality (odds ratio, 1.08; 95% CI, 1.01-1.16; P=0.014). Conclusions- Higher admission NLR is an independent predictor of symptomatic intracranial hemorrhage and 3-month mortality in large vessel occlusion patients treated with mechanical thrombectomy, and it may identify a target group for testing adjunctive anti-inflammatory therapies.
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