初乳
糖蛋白
牛乳
哺乳期
乳清蛋白
化学
食品科学
乳铁蛋白
生物化学
生物
抗体
免疫学
遗传学
怀孕
作者
Xueyan Cao,Mei Yang,Ning Yang,Xiaona Liang,Dongbing Tao,Biao Liu,Junrui Wu,Xiqing Yue
标识
DOI:10.1016/j.foodchem.2018.09.174
摘要
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins were identified in human colostrum and mature milk as well as bovine colostrum and mature milk whey. Gene Ontology and KEGG pathway analyses were used to elucidate the biological functions of whey N-glycoproteins in human and bovine colostrum and mature milks. Whey N-glycoproteomes differed dramatically between human and bovine milks and across lactation stages. The conserved and specific whey N-glycoproteins in all four sample types were also determined. Our results improve understanding of the properties and biological functions of whey N-glycoproteins in human and bovine milk and colostra, and provide insight into the potential application of some N-glycoproteins in infant formulae at different stages of development.
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